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首页> 外文期刊>Nature immunology >The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
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The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

机译：受体PD-1控制淋巴结和血液中的卵泡调节性T细胞

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摘要

CD4 + CXCR5 + Foxp3 + follicular regulatory T cells (T FR cells) inhibit humoral immunity mediated by CD4 + CXCR5 + Foxp3-follicular helper T cells (T FH cells). Although the inhibitory receptor PD-1 is expressed by both cell types, its role in the differentiation of T FR cells is unknown. Here we found that mice deficient in PD-1 and its ligand PD-L1 had a greater abundance of T FR cells in the lymph nodes and that those T FR cells had enhanced suppressive ability. We also found substantial populations of T FR cells in mouse blood and demonstrated that T FR cells in the blood homed to lymph nodes and potently inhibited T FH cells in vivo. T FR cells in the blood required signaling via the costimulatory receptors CD28 and ICOS but were inhibited by PD-1 and PD-L1. Our findings demonstrate mechanisms by which the PD-1 pathway regulates antibody production and help reconcile inconsistencies surrounding the role of this pathway in humoral immunity.
机译：CD4 + CXCR5 + Foxp3 +滤泡调节性T细胞（T FR细胞）抑制CD4 + CXCR5 + Foxp3滤泡辅助性T细胞（TFH细胞）介导的体液免疫。尽管抑制受体PD-1由两种细胞类型表达，但其在T FR细胞分化中的作用尚不清楚。在这里，我们发现缺乏PD-1及其配体PD-L1的小鼠在淋巴结中具有更多的T FR细胞，这些T FR细胞具有增强的抑制能力。我们还发现了小鼠血液中大量的T FR细胞，并证明血液中的T FR细胞归巢于淋巴结并在体内有效抑制了T FH细胞。血液中的T FR细胞需要通过共刺激受体CD28和ICOS发出信号，但被PD-1和PD-L1抑制。我们的发现证明了PD-1途径调节抗体产生并帮助调和围绕该途径在体液免疫中的作用的不一致的机制。

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