Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Pulko Vesna; Davies John S.; Martinez Carmine; Lanteri Marion C.; Busch Michael P.; Diamond Michael S.; Knox Kenneth; Bush Erin C.; Sims Peter A.; Sinari Shripad; Billheimer Dean; Haddad Elias K.; Murray Kristy O.; Wertheimer Anne M.; Nikolich-Zugich Janko

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Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

机译：具有天然表型的人类记忆T细胞随着年龄的增长而积累，并对持久性病毒产生反应

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The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8(+) T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8(+) T cells, called 'memory T cells with a naive phenotype' (T-MNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8(+) T-MNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.

机译：随着年龄的增长，幼稚T细胞的数量减少，对新微生物感染的敏感性增加。在这里，我们描述了表型天真人类CD8（+）T细胞的一个先前未知的子集，该子集可快速分泌多种细胞因子以响应持久性病毒抗原，但转录不同于记忆和效应T细胞。这些CD8（+）T细胞（称为“具有幼稚表型的记忆性T细胞”）的频率（T-MNP细胞）随着年龄的增长和严重急性感染后的频率增加，并且与免疫系统对免疫系统的剩余能力负相关随着年龄的增长出现新的感染。 CD8（+）T-MNP细胞代表了持久性感染免疫治疗的潜在新靶标，如果需要真正的幼稚T细胞对抗原做出反应，则应从幼稚库中考虑和减去。

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《Nature immunology》 |2016年第8期|共10页
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Pulko Vesna; Davies John S.; Martinez Carmine; Lanteri Marion C.; Busch Michael P.; Diamond Michael S.; Knox Kenneth; Bush Erin C.; Sims Peter A.; Sinari Shripad; Billheimer Dean; Haddad Elias K.; Murray Kristy O.; Wertheimer Anne M.; Nikolich-Zugich Janko;
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正文语种 eng
中图分类医学免疫学;
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1. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses [J] . Pulko Vesna, Davies John S., Martinez Carmine, Nature immunology . 2016,第8期

机译：具有天然表型的人类记忆T细胞随着年龄的增长而积累，并对持久性病毒产生反应
2. Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype. [J] . Dengler TJ, Pober JS The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第10期

机译：人血管内皮细胞刺激记忆，但不刺激幼稚的CD8 + T细胞分化为CTL，从而保留早期激活表型。
3. Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype [J] . Thomas J. Dengler, Jordan S. Pober The journal of immunology . 2000,第10期

机译：人类血管内皮细胞刺激记忆，但不刺激幼稚的CD8 + T细胞分化为CTL，从而保留早期激活表型
4. A novel mouse model of human breast cancer stem-like cells with high CD44+CD24-/lower phenotype metastasis to human bone [C] . World congress on breast diseases . 2008

机译：一种新型小鼠模型的人乳腺癌干燥细胞，具有高CD44 + CD24- /较低的人骨表型转移
5. Associations of T-cell phenotypes with persistent oral thrush at CD4 positive cell counts greater than 500 per cubic millimeter and their interactions with progression of HIV disease (Immune deficiency). [D] . Foster, Virginia Brown. 2001

机译：T细胞表型与持续口鹅口疮在CD4阳性细胞数上的关联大于每立方毫米500，以及它们与HIV疾病进展（免疫缺陷）的相互作用。
6. Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses [O] . Vesna Pulko, John S. Davies, Carmine Martinez, -1

机译：具有天真的表型的人类记忆T细胞会随着年龄的增长而积累并对持久性病毒产生反应
7. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses [O] . Vesna Pulko, John S Davies, Carmine Martinez, 2016

机译：人类记忆T细胞具有幼稚表型积累的衰老并响应持续的病毒

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

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