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首页> 外文期刊>Nature clinical practice. Rheumatology >How useful are synovial biopsies for the diagnosis of rheumatic diseases?
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How useful are synovial biopsies for the diagnosis of rheumatic diseases?

机译：滑膜活检对风湿性疾病的诊断有多大作用？

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摘要

The synovium is the area that is primarily affected by several arthritic diseases. It seems logical, therefore, to examine synovial tissue during diagnostic tests. In most cases, however, it is possible to make a diagnosis on the basis of clinical examination, routine laboratory tests, radiographic examination, and synovial fluid analysis only. The aspiration of fluid from a joint cavity can help to distinguish between inflammatory and noninflammatory arthropathies; when crystal-induced arthritis or septic arthritis is suspected, rapid analysis of synovial fluid is essential to establish a diagnosis before treatment is initiated. In the case of unclassified arthritis, or when synovial fluid cannot be aspirated, histologic examination of synovial tissue might lead to the correct diagnosis, and might alter therapy in selected cases. Blind needle biopsy is safe, well tolerated, technically simple, inexpensive, and can be performed in an outpatient setting. Over the last decade, high-definition, small-borearthroscopy in an outpatient setting under local anesthesia has triggered an upsurge in research on synovial tissue. The procedure is well tolerated and has a low rate of complications (<0.3%).
机译：滑膜是主要受几种关节炎疾病影响的区域。因此，在诊断测试期间检查滑膜组织似乎是合乎逻辑的。但是，在大多数情况下，仅根据临床检查，常规实验室检查，射线照相检查和滑液分析即可进行诊断。从关节腔抽吸液体可以帮助区分炎症性和非炎症性关节病。当怀疑是晶体诱发的关节炎或败血性关节炎时，对滑液进行快速分析对于在开始治疗之前进行诊断至关重要。对于未分类的关节炎，或无法抽出滑液时，对滑膜组织进行组织学检查可能会导致正确的诊断，并可能改变所选病例的治疗方法。盲针活检是安全的，耐受性良好，技术上简单，廉价的，并且可以在门诊进行。在过去的十年中，在局部麻醉下在门诊环境中进行高清，小腔镜检查已引起滑膜组织研究的热潮。该手术耐受性良好，并发症发生率低（<0.3％）。

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