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首页> 外文期刊>Nature clinical practice. Rheumatology >The changing epidemiology of gout.
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The changing epidemiology of gout.

机译：痛风流行病学的变化。

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Gout is one of the most common inflammatory arthritides, which is considered to be a true crystal deposition disorder caused by the formation of monosodium urate crystals in and around joints. A number of epidemiological studies from a diverse range of countries suggest that gout has increased in prevalence and incidence in recent years and that the clinical pattern of gout is becoming more complex. In particular, the greatest increase has been observed in primary gout in older men. Robust epidemiological studies have established risk factors for gout including genetic factors, excess alcohol consumption, purine-rich diet, the metabolic syndrome (obesity, hypertension, hyperlipidemia and insulin resistance), use of diuretics and chronic renal failure. Trends in alcohol use, diet, obesity and the metabolic syndrome in the general population might explain changes in the prevalence and incidence of gout in the community. Osteoarthritis, which is thought to predispose patients to monosodium urate crystal deposition in their joints, is becoming more prevalent as a consequence of increased longevity. In hospital settings, widespread diuretic use, increasing prevalence of end-stage renal failure and the success of organ transplant programmes have led to an increase in clinical complexity. Suboptimal management of gout is likely to have contributed to the rise in the prevalence of clinically overt, symptomatic, chronic gout.
机译：痛风是最常见的炎症性关节炎之一，被认为是由关节内及其周围尿酸单钠盐晶体形成引起的真正的晶体沉积障碍。来自不同国家的许多流行病学研究表明，近年来痛风的患病率和发病率有所增加，而且痛风的临床模式正在变得更加复杂。特别是，在老年男性中，原发性痛风的增加最大。健壮的流行病学研究已确定痛风的危险因素，包括遗传因素，过量饮酒，富含嘌呤的饮食，代谢综合征（肥胖，高血压，高脂血症和胰岛素抵抗），使用利尿剂和慢性肾功能衰竭。普通人群的饮酒，饮食，肥胖和代谢综合征的趋势可能解释了社区痛风的发生率和发生率的变化。骨关节炎被认为使患者容易在关节中沉积尿酸一钠晶体，但由于寿命的延长，骨关节炎正变得越来越普遍。在医院环境中，广泛使用利尿剂，晚期肾衰竭的流行率增加以及器官移植计划的成功导致临床复杂性的增加。痛风的欠佳管理可能导致临床上明显的，有症状的，慢性痛风的患病率上升。

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