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首页> 外文期刊>Nature immunology >RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.
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RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.

机译：RORgammat和共生菌群是产生粘膜白介素22的NKp46 +细胞分化所必需的。

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摘要

The mucosal immune system of the intestine is separated from a vast array of microbes by a single layer of epithelial cells. Cues from the commensal microflora are needed to maintain epithelial homeostasis, but the molecular and cellular identities of these cues are unclear. Here we provide evidence that signals from the commensal microflora contribute to the differentiation of a lymphocyte population coexpressing stimulatory natural killer cell receptors and the transcription factor RORgammat that produced interleukin 22 (IL-22). The emergence of these IL-22-producing RORgammathiNKp46+NK1.1(int) cells depended on RORgammat expression, which indicated that these cells may have been derived from lymphoid tissue-inducer cells. IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis.
机译：肠的粘膜免疫系统通过单层上皮细胞与大量微生物隔离。需要共生菌群的提示来维持上皮稳态，但是这些提示的分子和细胞特性尚不清楚。在这里，我们提供的证据表明，来自共生菌群的信号有助于共同表达刺激性自然杀伤细胞受体和产生白介素22（IL-22）的转录因子RORgammat的淋巴细胞群体的分化。这些产生IL-22的RORgammathiNKp46 + NK1.1（int）细胞的出现取决于RORgammat的表达，这表明这些细胞可能已衍生自淋巴样组织诱导细胞。这些细胞释放的IL-22促进了在维持粘膜稳态中重要的抗菌分子的产生。

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