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首页> 外文期刊>Nature immunology >Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.
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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.

机译：人胎儿淋巴组织诱导细胞是RORC + CD127 +自然杀伤样细胞产生白介素17的前体。

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摘要

The human body contains over 500 individual lymph nodes, yet the biology of their formation is poorly understood. Here we identify human lymphoid tissue-inducer cells (LTi cells) as lineage-negative RORC+ CD127+ cells with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Human LTi cells were committed natural killer (NK) cell precursors that produced interleukin 17 (IL-17) and IL-22. In vitro, LTi cells gave rise to RORC+ CD127+ NK cells that retained the ability to produce IL-17 and IL-22. Postnatally, similar populations of LTi cell-like cells and RORC+ CD127+ NK cells were present in tonsils, and both secreted IL-17 and IL-22 but no interferon-gamma. Our data indicate that lymph node organogenesis is controlled by an NK cell precursor population with adaptive immune features and demonstrate a previously unappreciated link between the innate and adaptive immune systems.
机译：人体包含500多个淋巴结，但对其形成的生物学了解甚少。在这里，我们确定人类淋巴组织诱导细胞（LTi细胞）为谱系阴性的RORC + CD127 +细胞，具有通过淋巴毒素和肿瘤坏死因子与间充质细胞相互作用的功能。人类LTi细胞是产生白介素17（IL-17）和IL-22的自然杀伤（NK）细胞前体。在体外，LTi细胞产生保留了产生IL-17和IL-22能力的RORC + CD127 + NK细胞。出生后，扁桃体中存在类似的LTi细胞样细胞和RORC + CD127 + NK细胞群体，并且都分泌IL-17和IL-22，但没有干扰素-γ。我们的数据表明，淋巴结器官的发生是由具有适应性免疫功能的NK细胞前体种群控制的，并证明了先天与适应性免疫系统之间未曾认识到的联系。

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