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首页> 外文期刊>Nature immunology >Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.
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Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.

机译：皮层窦探查，依赖S1P1的进入和基于流量的流出T细胞捕获。

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The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor type 1 probed the sinus surface but failed to enter the sinuses. In some sinuses, T cells became rounded and moved unidirectionally. T cells traveled from cortical sinuses into macrophage-rich sinus areas. Many T cells flowed from medullary sinuses into the subcapsular space. We propose a multistep model of lymph node egress in which cortical sinus probing is followed by entry dependent on sphingosine 1-phosphate receptor type 1, capture of cells in a sinus region with flow, and transport to medullary sinuses and the efferent lymph.
机译：淋巴结中淋巴细胞流出的细胞动力学定义不清。在这里，我们可视化了淋巴结皮质窦的分支组织，发现进入后，一些T细胞得以保留，而其他T细胞则返回了实质。缺乏1型神经鞘氨醇受体的T细胞探查了鼻窦表面，但未能进入鼻窦。在某些鼻窦中，T细胞呈圆形并单向移动。 T细胞从皮质窦进入富含巨噬细胞的窦区域。许多T细胞从髓窦流入囊下腔。我们提出了一种淋巴结流出的多步骤模型，其中皮质窦探查后进入，取决于1型鞘氨醇磷酸酯受体1，在有流量的窦区域捕获细胞，然后转运至髓窦和传出的淋巴。

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