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首页> 外文期刊>Nature immunology >Memory CD8~+T cell differentiation: initial antigen encounter triggers a developmental program in naive cells
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Memory CD8~+T cell differentiation: initial antigen encounter triggers a developmental program in naive cells

机译:记忆CD8〜+ T细胞分化:最初的抗原接触会触发幼稚细胞的发育程序

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摘要

The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naive CD8~+T cells become committed to dividing at least seven times and differentiating into effector and memory cells. Once the parental naive CD8~+T cell had been activated, this developmental process could not be interrupted and the daughter cells continued to divide and differentiate in the absence of further antigenic stimulation. These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8~+T cell formation.
机译:控制记忆T细胞分化的规则还没有被很好地理解。这项研究表明,抗原刺激后,原始的CD8〜+ T细胞至少会分裂七次,并分化为效应细胞和记忆细胞。一旦亲代幼稚的CD8〜+ T细胞被激活,这种发育过程就不会中断,并且子代细胞在没有进一步抗原刺激的情况下继续分裂和分化。这些数据表明,最初的抗原遭遇触发了指导性的发育程序,该程序不需要进一步的抗原刺激,并且直到记忆CD8 + T细胞形成才停止。

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