VE-cadherin phosphorylation decides: Vascular permeability or diapedesis

SidibéA.; ImhofB.A.

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VE-cadherin phosphorylation decides: Vascular permeability or diapedesis

机译：VE-钙黏着蛋白的磷酸化决定：血管通透性或尿布分离

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During an inflammatory response, leukocytes and fluids from the blood must reach the affected tissue. Tight regulation of endothelial junctions of the vascular endothelium is a critical molecular mechanism for controlling such events. VE-cadherin is a vascular endothelial adhesion molecule, specifically and exclusively expressed by endothelial cells, that controls integrity of blood vessels. In this issue of Nature Immunology, Wessel et al. report constitutive phosphorylation of VE-cadherin at Tyr731 in vivo and demonstrate that dephosphorylation of that residue contributes to leukocyte extravasation, whereas mediator-induced phosphorylation of VE-cadherin at Tyr685 results in vascular permeability.

机译：在发炎反应期间，血液中的白细胞和液体必须到达受影响的组织。严格调节血管内皮的内皮连接是控制此类事件的关键分子机制。 VE-钙粘着蛋白是一种血管内皮粘附分子，由血管内皮细胞特异性地和专有地表达，它控制血管的完整性。在本期《自然免疫学》中，Wessel等人。报道了体内Tyr731 VE-钙粘蛋白的组成型磷酸化，并证明该残基的去磷酸化有助于白细胞外渗，而介体诱导的Tyr685 VE-钙粘蛋白的磷酸化导致血管通透性。

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《Nature immunology》 |2014年第3期|共3页
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SidibéA.; ImhofB.A.;
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正文语种 eng
中图分类医学免疫学;
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1. VE-cadherin phosphorylation decides: Vascular permeability or diapedesis [J] . SidibéA., ImhofB.A. Nature immunology . 2014,第3期

机译：VE-钙黏着蛋白的磷酸化决定：血管通透性或尿布分离
2. Phosphorylation of VE-cadherin is modulatedby haemodynamic forces and contributes to theregulation of vascular permeability in vivo [J] . Fabrizio Orsenigo, Costanza Giampietro, Aldo Ferrari, Nature Communications . 2012,第11期

机译：VE-钙黏着蛋白的磷酸化受到血流动力学力的调节，并有助于体内血管通透性的调节
3. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo [J] . Fabrizio Orsenigo, Costanza Giampietro, Aldo Ferrari, Nature Communications . 2012,第2010期

机译：VE-钙黏着蛋白的磷酸化受到血流动力学力的调节，并有助于体内血管通透性的调节
4. MODEL SIMULATIONS REVEAL VCAM-1 AUGMENT PAK ACTIVATION RATES TO AMPLIFY P38 MAPK AND VE-CADHERIN PHOSPHORYLATION [C] . Eric Weidert, Vayal Khanna, Francisco Vital-Lopez, ASME summer bioengineering conference;SBC2012 . 2012

机译：模型模拟显示VCAM-1增强PAK激活速率来扩增P38 MAPK和VE-钙粘蛋白磷酸化
5. The role of specific alternative splice variants of vascular endothelial growth factor/vascular permeability factor in murine multistage skin carcinogenesis. [D] . Tober, Kathleen Lynn. 2001

机译：血管内皮生长因子/血管通透性因子的特定替代剪接变体在小鼠多阶段皮肤癌变中的作用。
6. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo [O] . Fabrizio Orsenigo, Costanza Giampietro, Aldo Ferrari, -1

机译：VE-钙黏着蛋白的磷酸化受到血流动力学力的调节并有助于体内血管通透性的调节
7. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo [O] . Orsenigo, Fabrizio, Giampietro, Costanza, Ferrari, Aldo, 2012

机译：VE-钙黏着蛋白的磷酸化受到血流动力学力的调节，并有助于体内血管通透性的调节

VE-cadherin phosphorylation decides: Vascular permeability or diapedesis

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