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首页> 外文期刊>Nature immunology >Coincidence detection of antibodies and interferon for sensing microbial context
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Coincidence detection of antibodies and interferon for sensing microbial context

机译：抗体和干扰素的同时检测，以检测微生物环境

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Cells are bathed by a sea of extracellular molecules that can trigger signals in cells expressing the corresponding receptors. Every cell expresses thousands of different receptors that use a variety of signaling mechanisms. How multiple intracellular signals that are triggered at a given time in a given cell are integrated, and how this integration determines the quality of cell responses, are poorly understood. In this issue of Nature Immunology, Bezbradica et al. show that the high-affinity FcyRI receptor for the Fc portion of immunoglobulin G (IgG) and the IFN-yR receptor for interferon-y (IFN-y) act together in mouse macrophages to generate signals that induce a unique subset of genes encoding molecules involved in antimicrobial effector mechanisms that are not induced by either receptor separately1 (Fig. 1).Among the other effector molecules they induce, microbial infections induce the production of IFN-y and IgG antibodies by the immune system. Those activate effector cells such as macrophages, which express specific receptors for both types of molecules. IFN-yR is a cytokine receptor that binds IFN-y with high affinity. IFN-yR signals via a typical pathway dependent on Jakkinases and STAT transcription factors when engaged by IFN-y. FcyRI is an irnmu-noreceptor with high affinity for one subclass (IgG2a in mice) or several subclasses (IgGl, IgG3 and IgG4 in humans) of IgG antibodies. FcyRI can bind antibodies as monomers; i.e., when not in complex with antigen. Fc receptor-borne antibodies resemble the B cell antigen receptor (BCR) on B cells. They activate cells when they are engaged by specific plurivalent antigens. FcyRI signals via immunoreceptor tyrosine-based activation motifs ITAMs) present in the intracytoplasmic domains of the transmembrane homodimer FcRy that associates with FcyRI.
机译：细胞被大量细胞外分子沐浴，这些细胞可以触发表达相应受体的细胞中的信号。每个细胞表达使用各种信号传导机制的数千种不同的受体。在给定时间在给定细胞中如何触发多个细胞内信号的整合，以及这种整合如何确定细胞反应的质量，人们了解得很少。在本期《自然免疫学》中，Bezbradica等人。表明免疫球蛋白G（IgG）的Fc部分的高亲和性FcyRI受体和干扰素γ的IFN-yR受体（IFN-y）在小鼠巨噬细胞中共同发挥作用，产生可诱导编码分子独特基因的信号（图1）参与了抗菌效应机制的研究（图1）。在它们诱导的其他效应分子中，微生物感染可诱导免疫系统产生IFN-γ和IgG抗体。那些激活效应细胞，例如巨噬细胞，其表达两种类型的分子的特异性受体。 IFN-γR是以高亲和力结合IFN-γ的细胞因子受体。当IFN-γ参与时，IFN-γR通过依赖于Jakkinases和STAT转录因子的典型途径发出信号。 FcyRI是一种免疫球蛋白受体，对IgG抗体的一个亚类（小鼠中的IgG2a）或几个亚类（人中的IgG1，IgG3和IgG4）具有高亲和力。 FcyRI可以结合抗体作为单体。即，当不与抗原复合时。 Fc受体携带的抗体类似于B细胞上的B细胞抗原受体（BCR）。当它们与特定的多价抗原结合时，它们会激活细胞。 FcyRI信号通过存在于与FcyRI相关的跨膜同型二聚体FcRy的胞内结构域中的基于免疫受体酪氨酸的激活基序（ITAM）发出。

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