Self-gratification yields not-so-naive T cells

MartinC.E.; SurhC.D.

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Self-gratification yields not-so-naive T cells

机译：自我满足会产生天真的T细胞

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Two current hypotheses address the importance of the avidity of the TCRfor self molecules during the response to foreign antigens. First, a model of 'coagonisrn has been proposed that is based on the observation that the recognition of noncognate self peptide-MHC by the TCR enhances the recognition of agonist foreign peptide-MHC complexes by naive T cells.

机译：当前的两个假设解决了在对外来抗原的反应过程中TCR对自身分子的亲和力的重要性。首先，已经提出了'coagonisrn'的模型，其基于以下观察：TCR对非同源自身肽-MHC的识别增强了天然T细胞对激动剂外源肽-MHC复合物的识别。

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《Nature immunology》 |2014年第3期|共3页
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MartinC.E.; SurhC.D.;
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正文语种 eng
中图分类医学免疫学;
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Self-gratification yields not-so-naive T cells

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