...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemistry >Hierarchical Classification of Glycoside Hydrolases
【24h】

Hierarchical Classification of Glycoside Hydrolases

机译：糖苷水解酶的分级分类

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review deals with structural and functional features of glycoside hydrolases, a widespread group of enzymes present in almost all living organisms. Their catalytic domains are grouped into 120 amino acid sequence-based families in the international classification of the carbohydrate-active enzymes (CAZy database). At a higher hierarchical level some of these families are combined in 14 clans. Enzymes of the same clan have common evolutionary origin of their genes and share the most important functional characteristics such as composition of the active center, anomeric configuration of cleaved glycosidic bonds, and molecular mechanism of the catalyzed reaction (either inverting, or retaining). There are now extensive data in the literature concerning the relationship between glycoside hydrolase families belonging to different clans and/or included in none of them, as well as information on phylogenetic protein relationship within particular families. Summarizing these data allows us to propose a multilevel hierarchical classification of glycoside hydrolases and their homologs. It is shown that almost the whole variety of the enzyme catalytic domains can be brought into six main folds, large groups of proteins having the same three-dimensional structure and the supposed common evolutionary origin.
机译：这篇评论涉及糖苷水解酶的结构和功能特征，糖苷水解酶是几乎所有活生物体中广泛存在的一组酶。在碳水化合物活性酶的国际分类（CAZy数据库）中，它们的催化结构域分为120个基于氨基酸序列的家族。在较高的等级层次上，其中一些家族合并为14个氏族。同一氏族的酶具有共同的进化基因起源，并具有最重要的功能特征，例如活性中心的组成，糖苷键裂解的端基构型以及催化反应的分子机理（转化或保留）。现在，文献中已有大量数据涉及属于不同氏族和/或不包含在不同氏族中的糖苷水解酶家族之间的关系，以及有关特定家族内系统进化蛋白关系的信息。总结这些数据使我们能够提出糖苷水解酶及其同系物的多层次分类。结果表明，几乎所有的酶催化域都可以分为六个主要折叠，即具有相同三维结构和假定的共同进化起源的大组蛋白质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号