A dRAStic RHOAdblock of Pyrin inflammasome activation

Dorfleutner Andrea; Stehlik Christian

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A dRAStic RHOAdblock of Pyrin inflammasome activation

机译：吡喃炎炎性体激活的严重RHOAdblock

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The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised in response to defects in the mevalonate pathway and is disabled directly by mutations in the gene encoding Pyrin, which results in the interleukin 1 beta (IL-1 beta)-driven autoinflammatory diseases MKD and FMF.

机译：如果小细胞GTPase的活性因甲羟戊酸途径的缺陷而受到损害，则Pyrin炎性体保护功能将被禁用，并且直接由编码Pyrin的基因突变而被禁用，从而导致白介素1 beta（IL-1 beta）驱动自身炎症性疾病MKD和FMF。

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《Nature immunology》 |2016年第8期|共4页
作者
Dorfleutner Andrea; Stehlik Christian;
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正文语种 eng
中图分类医学免疫学;
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1. A dRAStic RHOAdblock of Pyrin inflammasome activation [J] . Dorfleutner Andrea, Stehlik Christian Nature immunology . 2016,第8期

机译：吡喃炎炎性体激活的严重RHOAdblock
2. Free fatty acids impair autophagic activity and activate nuclear factor kappa B signaling and NLR family pyrin domain containing 3 inflammasome in calf hepatocytes [J] . Taiyu Shen, Xinwei Li, Bo Jin, Journal of dairy science . 2021,第11期

机译：游离脂肪酸损害自噬活性，并激活核因子Kappa B信令和NLR家族吡喃结构域，含有3只小牛肝细胞的炎症
3. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation [J] . Magupalli Venkat Giri, Negro Roberto, Tian Yuzi, Science . 2020,第6510期

机译：HDAC6为NLRP3和吡啶炎症组激活介导一种异常样机制
4. Does Metal Ion-induced Oxidative Stress Activate the Inflammasome in Macrophages? [C] . Maxime-Alexandre Ferko, Kriti Kumar, Isabelle Catelas Society for Biomaterials annual meeting and exposition . 2017

机译：金属离子诱导的氧化应激会激活巨噬细胞中的炎性体吗？
5. A study on involvement of elevation of uric acid level and inflammasome activation on nociception in mouse model of muscle pain. [D] . Yoshida Shinichirou 2019

机译：小鼠疼痛性肌肉痛模型中尿酸水平升高和炎症小体活化与伤害感受相关的研究。
6. A dRAStic RHOAdblock of Pyrin inflammasome activation [O] . Andrea Dorfleutner, Christian Stehlik -1

机译：吡喃炎炎症小体活化的DRAStic RHOAdblock
7. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy [O] . Deepika Sharma, Ankit Malik, Clifford Guy, 2018

机译：TNF / TNFR轴促进吡林炎症体激活，明显调节吡啶炎症病变

A dRAStic RHOAdblock of Pyrin inflammasome activation

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