Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

Lin CY; Graca L; Cobbold SP; Waldmann H

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Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

机译：显着的移植耐受性损害CD8 + T细胞功能，但不损害其扩增。

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Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection, interferon-gamma production and cell-mediated cytotoxicity. These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses.

机译：同种异体反应性CD8 + T细胞可能会在耐受移植组织的动物体内持续存在。它们的功能通过调节性CD4 + T细胞的持续检查来控制。我们试图建立这种审查制度的运作阶段。我们发现，引入耐受性动物的单特异性CD8 + T细胞对耐受的组织抗原有反应，就好像它们已经接受了CD4 + T细胞的“帮助”一样：它们正常增殖和积累。但是，它们确实显示出受损的移植物排斥，γ-干扰素产生和细胞介导的细胞毒性。这些发现表明，由调节性T细胞介导的耐受性通过检查免疫效应子功能而不是通过限制T细胞应答的诱导而起作用。

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《Nature immunology》 |2002年第12期|共6页
作者
Lin CY; Graca L; Cobbold SP; Waldmann H;
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正文语种 eng
中图分类基础医学;
关键词
CD8-Positive T-Lymphocytes; Immune Tolerance; Transplantation Immunology; CD8阳性T淋巴细胞; 免疫耐受; 移植免疫学;

机译：CD8-Positive T-Lymphocytes;Immune Tolerance;Transplantation Immunology;CD8阳性T淋巴细胞;免疫耐受;移植免疫学;

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1. Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. [J] . Lin CY, Graca L, Cobbold SP, Nature immunology . 2002,第12期

机译：显着的移植耐受性损害CD8 + T细胞功能，但不损害其扩增。
2. Induction of transplantation tolerance in haploidenical transplantation under reduced intensity conditioning: the role of ex-vivo generated donor CD8+ T cells with central memory phenotype. [J] . Ophir E, Eidelstein Y, Bachar Lustig E, Best practice & research: Clinical haematology . 2011,第3期

机译：在降低强度的条件下在单倍体移植中诱导移植耐受：离体产生的具有中央记忆表型的供体CD8 + T细胞的作用。
3. Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. [J] . Steptoe RJ, Ritchie JM, Wilson NS, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第4期

机译：静止的树突状细胞引起的同源CD4 +帮助不会损害CD8 + T细胞对外周耐受的诱导。
4. Hematopoietic Stem Cell Transplantation across Major Genetic Barriers: Tolerance Induction by Megadose CD34 Cells and Other Veto Cells [C] . YAIR REISNER, HILIT GUR, SHLOMIT REICH-ZELIGER, International Conference and Workshop on Hematopoietic Stem Cells . 2005

机译：造血干细胞移植跨重大遗传障碍：Megadose CD34细胞和其他否决细胞的耐受性诱导
5. Mechanisms of Deletional Tolerance of Peripheral CD8+ T Cells Induced by Anti-CD40L and Allogeneic Bone Marrow Transplantation [D] . Lucas, Carrie Lynn 2010

机译：抗CD40L和同种异体骨髓移植诱导的外周CD8 + T细胞的耐受性机制
6. STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T cell memory formation and function [O] . Megan L Ives, Cindy S Ma, Umaimainthan Palendira, -1

机译：常染色体显性遗传性高IgE综合征潜在的STAT3突变损害人类CD8 + T细胞记忆形成和功能
7. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function [O] . Ives, Megan L., Ma, Cindy S., Palendira, Umaimainthan, 2013

机译：常染色体显性遗传性高IgE综合征的信号转导和转录激活因子3（sTaT3）突变会损害人类CD8 + T细胞记忆的形成和功能

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

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