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首页> 外文期刊>Nature immunology >Lipid length controls antigen entry into endosomal and nonendosomal pathways for CDIb presentation
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Lipid length controls antigen entry into endosomal and nonendosomal pathways for CDIb presentation

机译：脂质长度控制抗原进入CDIb呈递的内体和非内体途径

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摘要

CDI proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C_(80)) alkyl chains involves the delivery of CDIb proteins and antigens to late endosomes in a process that takes several hours. In contrast, analogs of the same antigen with shorter (C_(32)) alkyl chains are rapidly, but inefficiently, presented by cell surface CDIb proteins. Dendritic cells (DCs) preferentially present long-chain glycolipids, which results, in part, from their rapid internalization and selective delivery of antigens to endosomal compartments. Nonprofessional antigen-presenting cells, however, preferentially present short-chain glycolipids because of their lack of prominent endosomal presentation pathways. Because long alkyl chain length distinguishes certain microbial glycolipids from common mammalian glycolipids, these findings suggest that DCs use a specialized endosomal-loading pathway to promote preferential recognition of glycolipids with a more intrinsically foreign structure.
机译：CDI蛋白将各种糖脂抗原呈递给T细胞，但控制哪种糖脂产生T细胞反应的细胞机制尚不清楚。我们在这里显示，具有长的（C_（80））烷基链的葡萄糖单霉菌抗原的T细胞识别涉及CDIb蛋白和抗原向过程的晚期内体的传递，过程需要几个小时。相反，具有较短（C_（32））烷基链的相同抗原的类似物由细胞表面CDIb蛋白迅速但效率低下。树突状细胞（DC）优先呈现长链糖脂，部分原因是它们迅速内在化并将抗原选择性递送至内体区室。然而，非专业的抗原呈递细胞由于缺乏突出的内体呈递途径而优先呈递短链糖脂。因为长的烷基链长将某些微生物糖脂与普通的哺乳动物糖脂区分开来，所以这些发现表明DC使用专门的内体负载途径来促进优先识别具有更本质上为外来结构的糖脂。

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