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首页> 外文期刊>Nature immunology >Protective neutralizing influenza antibody response in the absence of T follicular helper cells
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Protective neutralizing influenza antibody response in the absence of T follicular helper cells

机译：T滤泡辅助细胞不存在时的保护性中和流感病毒抗体反应

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摘要

Virus infection induces the development of T follicular helper (T-FH) and T helper 1 (T(H)1) cells. Although T-FH cells are important in anti-viral humoral immunity, the contribution of T(H)1 cells to a protective antibody response remains unknown. We found that IgG2 antibodies predominated in the response to vaccination with inactivated influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAV strains, even in mice that lacked T-FH cells and germinal centers. The cytokines interleukin-21 and interferon-gamma, which are secreted from T(H)1 cells, were essential for the observed greater persistence and higher titers of IgG2 protective antibodies. Our results suggest that T(H)1 induction could be a promising strategy for producing effective neutralizing antibodies against emerging influenza viruses.
机译：病毒感染诱导T卵泡辅助细胞（T-FH）和T辅助细胞1（T（H）1）的发育。尽管T-FH细胞在抗病毒体液免疫中很重要，但是T（H）1细胞对保护性抗体应答的贡献仍然未知。我们发现IgG2抗体在灭活的甲型流感病毒（IAV）的疫苗接种反应中占主导地位，即使在缺乏T-FH细胞和生发中心的小鼠中，也可对致病性H5N1和大流行性H1N1 IAV毒株进行致命性攻击提供保护性免疫。 T（H）1细胞分泌的白细胞介素21和干扰素-γ是观察到的更大持久性和更高滴度的IgG2保护性抗体所必需的。我们的结果表明，T（H）1诱导可能是产生针对新兴流感病毒的有效中和抗体的有前途的策略。

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