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首页> 外文期刊>Nature immunology >Phosphatase PP2A is requisite for the function of regulatory T cells
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Phosphatase PP2A is requisite for the function of regulatory T cells

机译：磷酸酶PP2A是调节性T细胞功能所必需的

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摘要

Homeostasis of the immune system depends on the proper function of regulatory T cells (T-reg cells). Compromised suppressive activity of T-reg cells leads to autoimmune disease and graft rejection and promotes anti-tumor immunity. Here we report a previously unrecognized requirement for the serine-threonine phosphatase PP2A in the function of T-reg cells. T-reg cells exhibited high PP2A activity, and T-reg cell-specific ablation of the PP2A complex resulted in a severe, multi-organ, lymphoproliferative autoimmune disorder. Mass spectrometry revealed that PP2A associated with components of the mTOR metabolic-checkpoint kinase pathway and suppressed the activity of the mTORC1 complex. In the absence of PP2A, T-reg cells altered their metabolic and cytokine profile and were unable to suppress effector immune responses. Therefore, PP2A is required for the function of T-reg cells and the prevention of autoimmunity.
机译：免疫系统的稳态取决于调节性T细胞（T-reg细胞）的正常功能。 T-reg细胞的抑制活性受损会导致自身免疫性疾病和移植排斥，并促进抗肿瘤免疫力。在这里，我们报告以前无法识别的T-reg细胞功能中丝氨酸-苏氨酸磷酸酶PP2A的要求。 T-reg细胞表现出高PP2A活性，而PP-2A复合物的T-reg细胞特异性消融导致严重的多器官淋巴组织增生性自身免疫疾病。质谱分析表明，PP2A与mTOR代谢检查点激酶途径的组分相关，并抑制了mTORC1复合物的活性。在没有PP2A的情况下，T-reg细胞改变了它们的代谢和细胞因子谱，并且无法抑制效应子免疫反应。因此，PP2A是T-reg细胞功能和预防自身免疫所必需的。

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