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首页> 外文期刊>Nature clinical practice. Rheumatology >Primer: making sense of T-cell memory.
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Primer: making sense of T-cell memory.

机译：入门：理解T细胞记忆。

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Protective memory is a key property of the immune system. Pathogen-associated molecular patterns of invading organisms deliver signals to pattern-recognition receptors that activate the innate immune system. Ligation of the T-cell receptor by peptides bound to MHC antigens and presented by dendritic cells, together with signals produced by the activated innate immune system, initiate T-cell responses. The nature of the T-cell response, consisting of phases of clonal expansion and contraction, and differentiation to effector and memory cells, however, is determined both by the properties of the antigen and the co-stimuli produced by the innate immune system. Short-lived effector and longer-lived memory T cells are generated during primary responses; after the death of most of the effectors, memory cells remain. Memory cells are heterogeneous in phenotype and function; subsets include the relatively quiescent central and more activated effector memory cells, as well as cells able to promote inflammation,help antibody production or regulate other immune responses. Understanding the properties of memory cells will help in the rational design of vaccines for 'difficult' organisms or cancer, as well as immunotherapies for autoimmune diseases.
机译：保护性记忆是免疫系统的关键特性。入侵生物的病原相关分子模式向激活先天免疫系统的模式识别受体传递信号。 T细胞受体与MHC抗原结合并由树突状细胞呈递的肽与激活的先天免疫系统产生的信号连接，引发T细胞反应。然而，由抗原的性质和先天免疫系统产生的共刺激物决定了T细胞应答的性质，该性质由克隆扩增和收缩的阶段以及向效应细胞和记忆细胞的分化组成。短暂的效应子和更长寿的记忆T细胞是在初级反应期间产生的。大多数效应物死亡后，记忆细胞仍然存在。记忆细胞在表型和功能上是异质的。亚类包括相对静止的中枢和更多激活的效应记忆细胞，以及能够促进炎症，帮助抗体产生或调节其他免疫反应的细胞。了解记忆细胞的特性将有助于合理设计针对“难”生物或癌症的疫苗，以及针对自身免疫性疾病的免疫疗法。

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