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首页> 外文期刊>Nature clinical practice. Oncology >The impact of histopathologic diagnosis on the proper management of testis neoplasms.
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The impact of histopathologic diagnosis on the proper management of testis neoplasms.

机译：组织病理学诊断对睾丸肿瘤正确处理的影响。

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BACKGROUND: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. INVESTIGATIONS: Brain MRI and CT-guided biopsy. DIAGNOSIS: Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. MANAGEMENT: High-dose methotrexate alone or in combination with high-dose cytarabine.
机译：背景：一名45岁男子因睾丸肿块迅速增大而接受了右睾丸切除术。经组织学和影像学检查后，患者被诊断为I期（T1N0M0）精原细胞瘤。手术大约2个月后，患者开始抱怨腹部疼痛，CT扫描显示腹膜后肿块较大。患者未接受计划的预防性放疗，并接受了顺铂，依托泊苷和博来霉素的联合化疗。治疗完成后，他实现了完全缓解。三年后，尽管仍在进行随访，但患者出现了多发性神经运动障碍。调查：脑MRI和CT引导下的活检。诊断：睾丸弥漫性大B细胞淋巴瘤，复发于中枢神经系统。管理：单独或与大剂量阿糖胞苷合用大剂量甲氨蝶呤。

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