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首页> 外文期刊>Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association >Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.
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Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.

机译：摄入高水平溶解氢（H2）的水可抑制Dahl盐敏感性大鼠的缺血性心肾损伤。

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摘要

BACKGROUND: Hydrogen (H(2)) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals. We studied the biological effects of water with dissolved H(2) on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD). METHODS: Dahl salt-sensitive rats (7 weeks old) were allowed ad libitum drinking of filtered water (FW: dissolved H(2), 0.00 +/- 0.00 mg/L) or water with dissolved H(2) produced by electrolysis (EW: dissolved H(2), 0.35 +/- 0.03 mg/L) for up to 6 weeks on a 0.5% salt diet. The rats then underwent ischemic reperfusion (I/R) of one kidney and were killed a week later for investigation of the contralateral kidney and the heart. RESULTS: In the rats given FW, unilateral kidney I/R induced significant increases in plasma monocyte chemoattractant protein-1, methylglyoxal and blood urea nitrogen. Histologically, significant increases were found in glomerular adhesion, cardiac fibrosis, number of ED-1 (CD68)-positive cells and nitrotyrosine staining in the contralateral kidney and the heart. In rats given EW, those findings were significantly ameliorated and there were significant histological differences between rats given FW and those given EW. CONCLUSION: Consumption of EW by ad libitum drinking has the potential to ameliorate ischemia-induced cardio-renal injury in CKD model rats. This indicates a novel strategy of applying H(2) produced by water electrolysis technology for the prevention of CKD cardio-renal syndrome.
机译：背景：据报道，氢（H（2））通过淬灭细胞毒性氧自由基产生抗氧化作用。我们在慢性肾脏病（CKD）大鼠模型中研究了水与溶解的H（2）对缺血诱导的心肾损伤的生物学效应。方法：让Dahl盐敏感性大鼠（7周大）随意饮用过滤水（FW：溶解H（2），0.00 +/- 0.00 mg / L）或电解产生的溶解H（2）的水（ EW：以0.5％的盐饮食最多可溶解6周的H（2），0.35 +/- 0.03 mg / L）。然后，对大鼠进行一个肾脏的缺血再灌注（I / R），并在一周后处死小鼠以研究对侧肾脏和心脏。结果：在接受FW的大鼠中，单侧肾脏I / R引起血浆单核细胞趋化蛋白1，甲基乙二醛和血尿素氮的显着增加。从组织学上看，对侧肾脏和心脏的肾小球粘附，心脏纤维化，ED-1（CD68）阳性细胞数量和硝基酪氨酸染色显着增加。在接受EW的大鼠中，这些发现得到了明显改善，在接受EW的大鼠与接受EW的大鼠之间存在明显的组织学差异。结论：随意饮水消耗EW有改善CKD模型大鼠缺血性心肾损伤的潜力。这表明应用水电解技术生产的H（2）预防CKD心肾综合征的新策略。

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