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首页> 外文期刊>Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association >The children of dialysis: Live-born babies from on-dialysis mothers in Italy - An epidemiological perspective comparing dialysis, kidney transplantation and the overall population
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The children of dialysis: Live-born babies from on-dialysis mothers in Italy - An epidemiological perspective comparing dialysis, kidney transplantation and the overall population

机译：透析的孩子：意大利透析母亲的活产婴儿-比较透析，肾脏移植和总人口的流行病学观点

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Background A successful pregnancy is an exceptional event on dialysis. Few data are available comparing pregnancy rates on dialysis, transplantation and the overall population. The aim of the study was to assess the incidence of live births from mothers on chronic dialysis compared with the overall population and with kidney transplant patients. Methods The setting of the study is in Italy between 2000-12. Data on dialysis was aquired by phone inquiries that were carried out between June and September, 2013, involving all the public dialysis centres in Italy; the result was a 100% response rate. The date included was end-stage renal disease, type of dialysis, residual glomerular filtration rate, changes in dialysis and therapy, hospitalization; week of birth, birth weight, centile; and outcome of mother and child. Information on transplantation was acquired by inquiry by the kidney and pregnancy study group who were contacted by phone or e-mail; the result was a 60% response rate. Data concerning prevalence of women in childbearing age (20-45) were obtained from the Italian Dialysis and Transplant Registries (2010-11 update). Official site of the Italian Ministry of Health. Results During the study period, 23 women on dialysis (three on peritoneal dialysis) delivered live-born babies and one woman delivered twins (24 babies). Three babies died in the first weeks-months of life (including one twin); 19 of 21 singletons with available data were pre-term (33.3% <34 weeks); the prevalence of children <10th gestational age-adjusted centile was 33.3%. Birth weight and gestational age were lower in children from on-dialysis mothers as compared with 110 pregnancies following kidney graft, (weight: 1200 versus 2500 g; gestational age: 30 versus 36 weeks; P < 0.001). Incidence of live-born babies was inferred as 0.7-1.1 per 1000 female dialysis patients aged 20-45 and 5.5-8.3 per 1000 grafted patients in the same age range (Italian live-birth rates: 72.5 per 1000 women aged 20-45 years). Conclusions Having a baby while on dialysis is rare but not impossible, though early mortality remains high. There is a 'scale of probability' estimating that women on dialysis have a 10-fold lower probability of delivering a live-born baby than those who have undergone renal transplantation, who in turn have a 10-fold lower probability of delivering a live-born baby as compared with the overall population.
机译：背景技术成功怀孕是透析的特殊事件。很少有数据可以比较透析，移植和总人口的妊娠率。这项研究的目的是评估与整体人口和肾移植患者相比，慢性透析母亲活产的发生率。方法：研究的地点是意大利的2000年12月。透析数据通过2013年6月至9月之间进行的电话查询获得，涉及意大利所有公共透析中心。结果是100％的响应率。日期包括终末期肾脏疾病，透析类型，肾小球滤过率残留，透析和治疗的变化，住院;出生周，出生体重，百分位数;和母子的结局。肾脏和妊娠研究小组通过电话或电子邮件联系询问，获得了移植信息。结果是60％的响应率。有关育龄妇女（20-45岁）患病率的数据来自意大利透析和移植注册中心（2010-11更新）。意大利卫生部的官方网站。结果在研究期间，有23名接受透析的妇女（三名接受腹膜透析）分娩了活产婴儿，一名妇女分娩了双胞胎（24名婴儿）。在生命的头几周中有3个婴儿死亡（包括一个双胞胎）;有数据的21例单胎中有19例为早产儿（33.3％<34周）;小于10个胎龄的儿童的患病率为33.3％。接受透析的母亲的孩子出生时的体重和胎龄比移植肾后的110例要低（体重：1200对2500 g;胎龄：30对36周; P <0.001）。据推断，在相同年龄范围内，每1000名20-45岁的女性透析患者的活产婴儿发生率分别为0.7-1.1和每1000名嫁接患者的5.5-8.3（意大利活产率：每1000名20-45岁女性中有72.5名）。结论虽然透析的早期死亡率仍然很高，但在透析过程中生婴儿的情况很少见，但并非不可能。有一个“概率规模”估计，接受透析的妇女分娩活产婴儿的可能性比接受肾移植的妇女低10倍，而接受肾移植的妇女则比接受肾移植的妇女低10倍。出生婴儿与总人口相比。

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