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首页> 外文期刊>Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association >Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin
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Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin

机译:环孢素A和美满霉素对阿霉素诱导的线粒体不平衡相关足细胞损伤和蛋白尿的发生具有保护作用

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摘要

Background. Dysfunction of mitochondria is involved in podocyte injury in some kidney diseases, but the relationship between abnormal mitochondrial morphology and podocyte injury as well as the underlying mechanism is still unclear. This study aims to investigate dynamic changes of mitochondrial morphology and the potential molecular events in an adriamycin (ADR)-induced podocyte injury model.
机译:背景。在一些肾脏疾病中,线粒体功能障碍与足细胞损伤有关,但是线粒体形态异常与足细胞损伤之间的关系及其潜在机制尚不清楚。这项研究旨在调查线粒体形态的动态变化和阿霉素(ADR)诱导足细胞损伤模型中的潜在分子事件。

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