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首页> 外文期刊>Mycotoxin Research >Effects of deoxynivalenol in naturally contaminated wheat on feed intake and health status of horses
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Effects of deoxynivalenol in naturally contaminated wheat on feed intake and health status of horses

机译：天然污染小麦中脱氧雪腐烯醇对马饲料摄入和健康状况的影响

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摘要

The present study examined the short-term effects of deoxynivalenol (DON), administered at two different concentrations via a feed preparation using naturally contaminated wheat, on feed intake, liver and kidney metabolism and immunomodulatory properties in horses. Twelve geldings were randomly assigned to one of three dietary treatments for 21 days. DON was provided via naturally contaminated wheat (14.6±6.5 mg DON/kg dry matter). The daily feed intake was adjusted to 4 kg of wheat and 1.7 kg of silage per 100 kg of body weight (BW). Horses were fed one of the following diets: control wheat with 0 % contaminated wheat (CON), wheat mixture containing 53±2 % of DON-contaminated wheat [low DON intake (LDI)] or wheat mixture containing 7 8 ±4 % of DON-contaminated wheat [high DON intake (HDI)]. CON, LDI and HDI corresponded to a targeted daily DON intake via the complete ration of <5, 50 and 75 u.g/kg BW, respectively. None of the horses demonstrated any clinical signs commonly associated with theintake of DON such as colic or depression. HDI was associated with lower daily wheat intake on day 21. Semm DON concentrations increased with higher DON intake. The non-toxic DON metabolite, deepoxy-deoxynivalenol (DOM-1) was only detected on day 21 of the DON feeding period. No changes in haematological and serum parameters or serum globulins or inthe ex vivo proliferation response of peripheral blood mononuclear cells were observed. These results suggest that horses are less sensitive to DON exposure than other domestic species, for example, swine. Therefore, the European Commission guidance value for critical DON concentrations in swine feed (complete diet) of 0.9 mg/kg could be safely applied for rations intended for feeding adult horses as well.
机译：本研究研究了使用天然污染小麦通过饲料制备两种不同浓度的脱氧雪腐烯醇（DON）对马的饲料摄入，肝肾代谢和免疫调节特性的短期影响。将十二种胶料随机分配为三种饮食疗法之一，持续21天。 DON是通过自然污染的小麦提供的（14.6±6.5 mg DON / kg干物质）。每100公斤体重（BW）的每日饲料摄入量调整为4公斤小麦和1.7公斤青贮饲料。给马饲喂以下饮食之一：对照小麦中掺有0％受污染的小麦（CON），小麦混合物中掺有53±2％的被DON污染的小麦[低DON摄入量（LDI）]或小麦混合物中掺有7 8±4％的小麦受DON污染的小麦[DON摄入量高（HDI）]。 CON，LDI和HDI分别通过完全定量的<5、50和75 u.g / kg BW分别对应于目标DON的每日摄入量。没有匹马表现出任何通常与呕吐毒素有关的临床症状，例如绞痛或抑郁。 HDI与第21天的每日小麦摄入量减少有关。血清DON的浓度随DON摄入量的增加而增加。仅在DON喂养期的第21天才检测到无毒的DON代谢产物，深氧-脱氧雪腐烯醇（DOM-1）。没有观察到血液学和血清学参数或血清球蛋白的变化或外周血单个核细胞的离体增殖反应的变化。这些结果表明，与其他家养物种（例如猪）相比，马对DON暴露的敏感性较低。因此，欧盟委员会关于猪饲料（完全日粮）中的关键DON浓度为0.9 mg / kg的指导值也可以安全地用于准备成年马饲料的日粮。

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