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首页> 外文期刊>Natural product research >The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.
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The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.

机译：雷公藤甲素对胶原性关节炎DA大鼠Peyer斑中CD4 +和CD8 +细胞的影响。

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摘要

Triptolide is a purified component from a traditional Chinese herb Tripterygium wilfordii Hook F. It has been shown to have anti-inflammatory and immunosuppressive activities by its inhibitory effect on T-cells. But the effect of triptolide on enteric mucosal immune responses is not well known. The enteric mucosal immune system, especially the Peyer's patch, is regarded as one of the sites for inducing immunity tolerance, and this intolerance effect has been used to induce oral tolerance, which can considerably reduce arthritis severity in several models of experimental polyarthritis and rheumatoid arthritis (RA) patients. In this study, we investigated the effect of triptolide on the CD4+ and CD8+ cell distribution in Peyer's patch cells and periphery lymphocytes and TGF-beta and IFN-gamma levels in periphery in collagen induced arthritis (CIA) in DA rats. CIA in the rat is a widely studied animal model of inflammatory polyarthritis, with similarities to RA, and the DA rat is one of most susceptible strains for CIA. Our data show that triptolide could lower the arthritic scores of CIA. The more CD8+ cells in the Peyer's patch, the more CD4+ cells in periphery. High level IFN-gamma and low level TGF-beta in periphery are observed in CIA rats, while the less CD4+ and CD8+ cells in the Peyer's patch, the less CD4+ cells in periphery. Low level IFN-gamma and high level TGF-beta in periphery are shown in triptolide-treated rats. The dose dependency of triptolide was observed in periphery CD4 cells and in the arthritic score. Therefore, the effect of triptolide on Peyer's patch immune cells might partially explain some of the immunosuppressive activities of triptolide.
机译：雷公藤内酯醇是传统中草药雷公藤（Triptygium wilfordii Hook F）的纯化成分。通过对T细胞的抑制作用，雷公藤内酯醇具有抗炎和免疫抑制作用。但是雷公藤甲素对肠粘膜免疫反应的影响尚不清楚。肠粘膜免疫系统，特别是Peyer斑片，被认为是诱导免疫耐受的部位之一，这种不耐受作用已被用于诱导口服耐受，在多种实验性多关节炎和类风湿关节炎模型中，它可以大大降低关节炎的严重程度（RA）患者。在这项研究中，我们研究了雷公藤内酯醇对DA大鼠胶原蛋白诱导的关节炎（CIA）的Peyer贴片细胞和外周淋巴细胞CD4 +和CD8 +细胞分布以及外周TGF-β和IFN-γ水平的影响。大鼠中的CIA是广泛研究的炎性多关节炎动物模型，与RA相似，而DA大鼠是CIA最易感的菌株之一。我们的数据表明雷公藤甲素可能降低CIA的关节炎评分。 Peyer's贴片中的CD8 +细胞越多，外围的CD4 +细胞越多。在CIA大鼠中观察到外周血中高水平的IFN-γ和低水平的TGF-β，而在Peyer's斑块中，CD4 +和CD8 +细胞越少，周围的CD4 +细胞越少。在雷公藤内酯醇治疗的大鼠中显示出外周水平低水平的IFN-γ和高水平的TGF-β。雷公藤甲素的剂量依赖性在外周CD4细胞和关节炎评分中观察到。因此，雷公藤甲素对派伊尔贴片免疫细胞的作用可能部分解释了雷公藤甲素的某些免疫抑制活性。

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