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首页> 外文期刊>Nature reviews. Nephrology >Stones: CSF-1 suppresses crystal formation.
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Stones: CSF-1 suppresses crystal formation.

机译：结石：CSF-1抑制晶体形成。

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Antiphospholipid syndrome (APS) is an autoimmune disease defined by the presence of arterial or venous thrombotic events and/or pregnancy morbidity in patients who test positive for antiphospholipid antibodies (aPLs). APS can be isolated (known as primary APS) or associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE; known as secondary APS). The kidney is a major target organ in APS and renal thrombosis can occur at any level within the vasculature of the kidney (renal arteries, intrarenal arteries, glomerular capillaries and renal veins); events reflect the site and size of the involved vessels. Histological findings vary widely, including ischaemic glomeruli and thrombotic lesions without glomerular or arterial immune deposits on immunofluorescence. Renal prognosis is affected by the presence of aPLs in patients with lupus nephritis and can be poor. In patients with SLE and aPLs, biopsy should be performed because inflammatory and thrombotic lesions require different therapeutic approaches. Renal involvement in patients with definite APS is treated by anticoagulation with long-term warfarin. The range of renal manifestations associated with APS is broadening and, therefore, aPLs have increasing relevance in end-stage renal disease, transplantation and pregnancy.
机译：抗磷脂综合症（APS）是一种自身免疫性疾病，定义为对抗磷脂抗体（aPLs）呈阳性的患者存在动脉或静脉血栓形成事件和/或妊娠发病率。 APS可以分离（称为原发性APS）或与其他自身免疫性疾病（例如系统性红斑狼疮（SLE;称为继发性APS））相关。肾脏是APS的主要靶器官，肾脏血栓形成可在肾脏脉管系统内的任何水平发生（肾动脉，肾内动脉，肾小球毛细血管和肾静脉）。事件反映了所涉船只的位置和大小。组织学发现差异很大，包括缺血性肾小球和血栓性病变，免疫荧光时无肾小球或动脉免疫沉积物。狼疮性肾炎患者中aPL的存在会影响肾脏的预后，并且可能很差。对于患有SLE和aPL的患者，应进行活检，因为炎性和血栓性病变需要不同的治疗方法。长期华法林抗凝治疗具有一定APS的肾脏受累。与APS相关的肾脏表现范围不断扩大，因此，aPL在终末期肾脏疾病，移植和妊娠中的相关性越来越高。

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