• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature reviews. Nephrology >The podocyte as a target for therapies-new and old
【24h】

The podocyte as a target for therapies-new and old

机译：足细胞作为新旧疗法的靶标

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Injury to the podocyte results in proteinuria and often leads to progressive kidney disease. As podocytes have limited ability to repair and/or regenerate, the extent of podocyte injury is a major prognostic determinant in diabetic nephropathy and other common causes of end-stage renal disease. Therapies aimed at preventing or limiting podocyte injury and/or at promoting podocyte repair or regeneration therefore have major potential clinical and economic benefits. Many current therapies-including glucocorticosteroids and calcineurin antagonists-have potent effects on podocytes. The nonspecific natures of these agents lead to undesirable systemic adverse effects: an agent with a more specific focus on podocytes would cause less treatment-associated morbidity. Recent years have seen dramatic advances in our understanding of podocyte biology and in particular regulation of its actin cytoskeleton, the major determinant of the complex architecture on which these cells depend for their function. This advance has allowed the identification of potential therapeutic targets and the next few years should see the development and testing of specific therapies aimed at the podocyte. Thus we are about to move from a situation where some of our 'blunderbuss' older therapies fortuitously happened to have beneficial effects on podocytes to a new era where advances in biological knowledge about a key cell type in the kidney will allow targeted drug design. As well as being intellectually more satisfying, every reason exists to believe that patients of the future will benefit and that the scourge of progressive kidney disease will be more effectively tackled.
机译：足细胞损伤导致蛋白尿，并经常导致进行性肾脏疾病。由于足细胞修复和/或再生的能力有限，足细胞损伤的程度是糖尿病性肾病和其他终末期肾脏疾病的常见病因的主要预后决定因素。因此，旨在预防或限制足细胞损伤和/或促进足细胞修复或再生的疗法具有重大的潜在临床和经济利益。当前的许多疗法，包括糖皮质激素和钙调神经磷酸酶拮抗剂，对足细胞都有有效作用。这些药物的非特异性性质会导致不良的全身性不良反应：更着重于足细胞的药物将导致较少的与治疗相关的发病率。近年来，在我们对足细胞生物学的理解，尤其是对其肌动蛋白细胞骨架的调控方面，已经取得了巨大的进步，肌动蛋白细胞骨架是这些细胞赖以运作的复杂结构的主要决定因素。这项进展已经可以确定潜在的治疗靶标，并且在接下来的几年中，应该会针对足细胞进行特定疗法的开发和测试。因此，我们将要从一些偶然的“失误”旧疗法偶然地对足细胞产生有益作用的局面转移到一个新时代，在这个新时代中，有关肾脏关键细胞类型的生物学知识的发展将使靶向药物设计成为可能。除了在理论上更加令人满意之外，还存在各种理由相信未来的患者将会受益，并且进展性肾脏疾病的祸害将得到更有效的解决。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号