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首页> 外文期刊>Mycotoxin Research >The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs
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The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs

机译：抗氧化剂饲料添加剂对减轻天然镰刀菌真菌毒素污染的玉米对断奶猪肠粘膜，血浆和肝脏中抗氧化剂系统的潜在影响

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Seventy-two piglets (6.0 kg BW) were randomly distributed within six different dietary treatments to evaluate the effect of deoxynivalenol (DON) and the potential of four antioxidant feed additives in mitigating the adverse effects of DON on growth performances and oxidative status. Dietary treatments were as follows: control diet 0.8 mg/kg DON; contaminated diet (DON-contaminated diet) 3.1 mg/kg DON; and four contaminated diets, each supplemented with a different antioxidant feed additive, DON + vitamins, DON + organic selenjum (Se)/glutathione (GSH), DON + quercetin, and DON + COMB (vitamins + Se/GSH + quercetin from the other treatments). Although DON was the main mycotoxin in the contaminated diet, this diet also contained 1.8 mg/kg of zearalenone (ZEN). The "mycotoxin" effects therefore included the combined effect of these two mycotoxins, DON, and ZEN. The DON-ZEN ingestion did not affect growth performances, average daily gain (ADG), average daily feed intake (ADFI), and feed efficiency (G:Fratio), but partially induced oxidative stress in weaned pigs as shown by increased malondialdehyde (MDA) content in the plasma and superoxide dismutase (SOD) activity in liver (P<0.05). However, no change in the activity of other antioxidant enzymes orGSH concentrations was observed in plasma and liver of piglets fedthe DON-contaminated diet (P>0.05). Supplementation with individual antioxidant feed additive had a limited effect in weaned pigs fed DON-ZEN-contaminated diets. Combination of antioxidants (vitamins A, C, and E, quercetin, and organic Se/GSH) reduced plasma and liver MDA content and SOD activity in liver (P< 0.05) of piglets fed DON-ZEN-contaminated diets. Furthermore, this combination also reduced MDA content in the ileum (P< 0.05), although activity of glutathione peroxidases (GPx), SOD or catalase (CAT) in the ileum was not affected by DON-ZEN contamination or antioxidant supplements. In conclusion, DON-ZEN contamination induced oxidative stress in weaned pigs and combination of antioxidant feed additives restored partially the oxidative status. Further studies will be necessary to assess whether the effects of antioxidant feed additives on oxidative status are specific when feed is contaminated with DON-ZEN.
机译：将72只仔猪（体重6.0千克体重）随机分配到6种不同的日粮处理中，以评估脱氧雪腐烯醇（DON）的作用以及四种抗氧化剂饲料添加剂缓解DON对生长性能和氧化状态的不利影响的潜力。饮食处理如下：对照饮食0.8 mg / kg DON;饮食污染（DON污染的饮食）3.1 mg / kg DON;和四种受污染的饮食，每种饮食均添加了不同的抗氧化剂饲料添加剂：DON +维生素，DON +有机硒精（Se）/谷胱甘肽（GSH），DON +槲皮素和DON + COMB（维生素+ Se / GSH +槲皮素）治疗）。尽管DON是受污染饮食中的主要真菌毒素，但该饮食中还含有1.8 mg / kg的玉米赤霉烯酮（ZEN）。因此，“霉菌毒素”作用包括这两种霉菌毒素DON和ZEN的联合作用。 DON-ZEN的摄入不会影响断奶仔猪的生长性能，平均日增重（ADG），平均日采食量（ADFI）和饲料效率（G：Fratio），但部分诱导氧化应激，如丙二醛（MDA）升高）血浆含量和肝脏超氧化物歧化酶（SOD）活性（P <0.05）。然而，在饲喂受DON污染的仔猪的血浆和肝脏中，未观察到其他抗氧化酶或GSH浓度的变化（P> 0.05）。补充单独的抗氧化剂饲料添加剂对饲喂受DON-ZEN污染的断奶仔猪的作用有限。抗氧化剂（维生素A，C和E，槲皮素和有机Se / GSH的组合）降低了饲喂受DON-ZEN污染的日粮的仔猪的血浆和肝脏MDA含量以及肝脏中的SOD活性（P <0.05）。此外，尽管DON-ZEN污染或抗氧化剂补充剂不影响回肠中谷胱甘肽过氧化物酶（GPx），SOD或过氧化氢酶（CAT）的活性，但这种组合也降低了回肠中的MDA含量（P <0.05）。总之，DON-ZEN污染可引起断奶仔猪的氧化应激，抗氧化剂饲料添加剂的组合可部分恢复氧化状态。有必要进行进一步的研究，以评估当饲料被DON-ZEN污染时，抗氧化剂饲料添加剂对氧化状态的影响是否具有特异性。

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