...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mycotoxin Research >Biomonitoring of concurrent exposure to ochratoxin A and citrinin in pregnant women in Bangladesh
【24h】

Biomonitoring of concurrent exposure to ochratoxin A and citrinin in pregnant women in Bangladesh

机译：孟加拉国孕妇同时摄入曲霉毒素A和西林毒素的生物监测

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ochratoxin A (OTA) and citrinin (CIT) are both nephrotoxic and teratogenic in animals, and the occurrence of these mycotoxins in food may cause adverse health effects in humans. Data on the combined exposure to these food contaminants are still scarce, especially in pregnancy. Therefore, a biomonitoring study was conducted to determine the presence of urinary biomarkers of exposure to OTA and CIT in pregnant women in Bangladesh. In total, 54 spot urine samples were collected from residents of a ruraland a suburban area of the Savar region in Dhaka district for analysis of OTA and CIT urinary biomarkers by previously validated HPLC-FD and LC-MS/MS methods. Most urines were positive for OTA and CIT biomarkers, with OTA being detected in 93 % (range 0.01-0.84 ng/mL) and CIT biomarkers in 87 % (range 0.02-6.93 ng/mL) of all samples. The mean levels of OTA were different between the rural (0.06 ±0.07 ng/mL) and suburban (0.15 ±0.19 ng/mL) study participants. CIT and its metabolite dihydrocitrinone (HO-CIT) were more than twofold higher in the rural (0.42 ±1.20 and 0.55 ±1.04 ng/mL, respectively) than the suburban (CIT 0.15±0.13 ng/mL; HO-CIT 0.23 ±0.18 ng/mL) participants. When a provisional daily intake for CIT was calculated, it exceeded the preliminary tolerable value set by European Food Safety Authority (0.2 ug/kg/day) in 9 % of the rural participants but in none ofthe urban participants. Urinary biomarker levels for OTA and CIT did not show significant association with intake of certain types of food consumed by the pregnant women, although total CIT biomarker levels were considerably higher among participants whoconsumed more rice in a day. Overall, this study indicates a frequent co-exposure to OTA and CIT among pregnant women in Bangladesh, at levels similar to those determined recently in the general population of this country.
机译：animals曲霉毒素A（OTA）和柑桔素（CIT）在动物中均具有肾毒性和致畸性，并且食物中这些霉菌毒素的出现可能对人类健康产生不利影响。关于这些食物污染物的综合暴露的数据仍然很少，尤其是在怀孕期间。因此，进行了一项生物监测研究，以确定孟加拉国孕妇暴露于OTA和CIT的尿液生物标志物。总共从达卡地区萨瓦地区农村和郊区居民中收集了54个尿样，通过先前验证的HPLC-FD和LC-MS / MS方法分析OTA和CIT尿液生物标志物。大多数尿液中的OTA和CIT生物标志物均为阳性，所有样品中的OTA检出率为93％（范围为0.01-0.84 ng / mL），CIT生物标志物为87％（范围为0.02-6.93 ng / mL）。农村地区（0.06±0.07 ng / mL）和郊区地区（0.15±0.19 ng / mL）的研究对象的OTA平均水平有所不同。农村地区的CIT及其代谢物二氢柠檬酸酮（HO-CIT）（分别为0.42±1.20和0.55±1.04 ng / mL）比郊区（CIT 0.15±0.13 ng / mL; HO-CIT 0.23±0.18）高出两倍以上ng / mL）参与者。计算CIT的每日临时摄入量时，在9％的农村参与者中，但没有一个城市参与者，它超过了欧洲食品安全局设定的初步允许值（0.2 ug / kg /天）。尽管一天摄入更多大米的参与者的总CIT生物标志物水平明显较高，但OTA和CIT的尿液生物标志物水平与孕妇食用的某些类型食物的摄入量没有显着相关。总体而言，这项研究表明孟加拉国孕妇经常同时接触OTA和CIT，其水平与该国总人口中最近确定的水平相似。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号