Diabetic nephropathy: Endothelin antagonism for diabetic nephropathy.

Sarafidis PA; Lasaridis AN

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Diabetic nephropathy: Endothelin antagonism for diabetic nephropathy.

机译：糖尿病肾病：内皮素拮抗糖尿病肾病。

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The ASCEND study was a large, international trial that aimed to assess the effects of avosentan on diabetic nephropathy. To the disappointment of the nephrology community who had anticipated that the trial would demonstrate beneficial effects of this treatment, ASCEND was terminated early owing to excessive rates of adverse events, such as congestive heart failure associated with avosentan use.

机译：ASCEND研究是一项大型国际试验，旨在评估阿伏生坦对糖尿病性肾病的影响。令肾脏病界失望的是，他们原本预期该试验将证明这种治疗的有益效果，但由于不良事件发生率过高（例如与使用阿伏生坦相关的充血性心力衰竭），ASCEND提前终止。

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《Nature reviews. Nephrology》 |2010年第8期|共3页
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Sarafidis PA; Lasaridis AN;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
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1. Diabetic nephropathy: Endothelin antagonism for diabetic nephropathy. [J] . Sarafidis PA, Lasaridis AN Nature reviews. Nephrology . 2010,第8期

机译：糖尿病肾病：内皮素拮抗糖尿病肾病。
2. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. [J] . Mehdi UF, Adams Huet B, Raskin Journal of the American Society of Nephrology: JASN . 2009,第12期

机译：在糖尿病性肾病中，最大程度地抑制血管紧张素转化酶会增加对血管紧张素受体的阻断或盐皮质激素的拮抗作用。
3. The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy. [J] . Dick de Zeeuw, Blai Coll, Dennis Andress, Journal of the American Society of Nephrology: JASN . 2014,第5期

机译：内皮素拮抗剂阿特拉森坦可降低2型糖尿病肾病患者的残留蛋白尿。
4. Detection of Serum Vascular Endothelial Growth Factor (VEGF) and Endothelin, in Type 2 Diabetic Nephropathy Patients and Its Clinical Significance [C] . Yongqiang Zheng, Jianfen Wei, Xiaojun Li, International conference on green communications and networks;GCN 2011 . 2011

机译：2型糖尿病肾病患者血清血管内皮生长因子（VEGF）和内皮素的检测及其临床意义
5. IgG pharmacokinetics in a rat model of type 2 diabetes mellitus and diabetic nephropathy. [D] . Chadha, Gurkishan Singh. 2015

机译：2型糖尿病和糖尿病肾病大鼠模型中的IgG药代动力学。
6. Which one of the following antihypertensive medications is the least appropriate choice for patients with diabetic nephropathy. Nifedipine (e.g. Adalat) is the least appropriate choice for patients with diabetic nephropathy. [O] . 1997

机译：以下哪种降压药物是糖尿病肾病患者最不适合的选择。硝苯地平（例如Adalat）是糖尿病肾病患者最不适合的选择。
7. Endothelin antagonism and diabetic erectile dysfunction: Changes in VEGF and NO in type I diabetic penis and effects of endothelin antagonism [O] . Jesmin Subrina, Zaedi Sohel, Shimojo Nobutake, 2013

机译：内皮素拮抗作用和糖尿病勃起功能障碍：I型糖尿病阴茎中VEGF和NO的变化以及内皮素拮抗作用
8. Agonists of A2A Adenosine Receptors for Treatment of Diabetic Nephropathy. [R] . Okusa, M. D., Linden, J. M., Macdonald, T. L., 2005

机译：a2a腺苷受体激动剂治疗糖尿病肾病。

Diabetic nephropathy: Endothelin antagonism for diabetic nephropathy.

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