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Functional imaging of renal cell carcinoma

机译：肾细胞癌的功能成像

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The incidence of early and advanced-stage renal cell carcinoma (RCC) is increasing. Methods of diagnosing, staging and evaluating tumor burden that are more accurate and reliable than the currently available options are needed in order to identify RCC at a stage at which it is curable and to accurately determine the response to treatment. Functional imaging, particularly with combined PET-CT, might improve accuracy of detection and provide essential information that has been unavailable to date. This approach is against a background in which targeted therapies for metastatic RCC have entered clinical practice in the past few years, further highlighting the importance of accurate imaging for patient selection and for monitoring response to treatment. We outline the current clinical status of functional imaging in RCC using PET-CT, which allows simultaneous capture and co-registration of functional and anatomical data. New radiotracers and approachesincluding radiolabeled monoclonal antibodies and imaging of tumor hypoxiaare touched on, and areas of future research discussed.
机译：早期和晚期肾细胞癌（RCC）的发病率正在增加。为了在可治愈的阶段识别RCC并准确确定对治疗的反应，需要比当前可用选项更准确和可靠的诊断，分期和评估肿瘤负荷的方法。功能成像，尤其是结合PET-CT的功能成像，可能会提高检测的准确性，并提供迄今为止尚无法获得的基本信息。这种方法的背景是，过去几年来转移性RCC的靶向治疗已进入临床实践，这进一步突出了准确成像对患者选择和监测治疗反应的重要性。我们概述了使用PET-CT在RCC中进行功能成像的当前临床状况，该功能允许同时捕获和共同注册功能和解剖数据。新的放射性示踪剂和方法，包括放射性标记的单克隆抗体和肿瘤缺氧的影像学，涉及了未来的研究领域。

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