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首页> 外文期刊>Nature reviews. Urology >Androgen suppression duration and zoledronic acid: under the RADAR
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Androgen suppression duration and zoledronic acid: under the RADAR

机译：雄激素抑制持续时间和唑来膦酸：在RADAR下

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Each year, more than 5,000 men in Australia and New Zealand are diagnosed with locally advanced prostate cancer. Unfortunately, in at least 25% of cases, the cancer has metastasized to the bone and lymph glands, and is undetectable by current imaging methods. As a result, these men cannot undergo active surveillance and instead require treatment for prolonged periods. Although long-term androgen suppression following radiotherapy has been shown to be more effective than short-term androgen suppression (STAS), longer-term treatment is also associated with greater morbidities, such as osteopenia and fractures. The Trans-Tasman Radiation Oncology Group (TROG) 96.01 trial determined the value of 6 months of STAS. In the USA and Europe, androgen suppression lasting 28-36 months was frequently used after other trials showed that longer duration could reduce prostate cancer mortality. However, long-term and sometimes permanent side effects included sexual dysfunction, hot flushes, breast enlargement and pain, shrinkage of the genitalia, anaemia, blood clots, fatigue, cognitive dysfunction, depression and reductions in bone mineral density resulting in fractures.
机译：每年，澳大利亚和新西兰的5,000多名男性被诊断出患有局部晚期前列腺癌。不幸的是，在至少25％的情况下，该癌症已转移至骨骼和淋巴腺，目前的影像学方法无法检测到。结果，这些男人不能接受主动监视，而是需要长期治疗。尽管已显示放疗后长期抑制雄激素比短期抑制雄激素（STAS）更有效，但长期治疗也与更大的发病率相关，例如骨质减少和骨折。 Trans-Tasman放射肿瘤学小组（TROG）96.01试验确定了6个月STAS的价值。在美国和欧洲，在其他试验表明更长的持续时间可以降低前列腺癌的死亡率后，经常使用持续28-36个月的雄激素抑制作用。然而，长期的，有时是永久的副作用包括性功能障碍，潮红，乳房增大和疼痛，生殖器萎缩，贫血，血凝块，疲劳，认知功能障碍，抑郁症和骨矿物质密度降低导致骨折。

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