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首页> 外文期刊>Nature reviews. Urology >Prostate cancer: Genetic markers of prostate cancer aggressiveness
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Prostate cancer: Genetic markers of prostate cancer aggressiveness

机译：前列腺癌：前列腺癌侵袭性的遗传标志

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Current prognostic tools lack sufficient accuracy to identify the subset of patients with aggressive prostate cancer who are at high risk of recurrence and death. Besides conventional clinical parameters, some genetic alterations including rearrangements in ETS transcription factor genes-the most common of which is the TMPRSS2-ERG fusion-have been linked to poor prognosis in this disease. Now, three new papers have shed light on potential genetic markers for aggressive prostate cancer. Combining data on ETS gene rearrangements and loss of the tumor suppressor gene PTEN predicts risk of death from prostate cancer. So says a team of researchers working on behalf of the Transatlantic Prostate Group. "Using gene status, we identified a group of patients that did very well, and a group of patients that did very badly," says lead author Alison Reid from the UK Institute of Cancer Research. "These results could have important implications for deciding which patients should be conservatively or aggressively treated."
机译：当前的预后工具缺乏足够的准确性来识别患有复发和死亡的高风险的侵略性前列腺癌患者的子集。除了常规的临床参数外，包括ETS转录因子基因重排在内的一些遗传改变（其中最常见的是TMPRSS2-ERG融合）与该疾病的不良预后有关。现在，三篇新论文阐明了侵略性前列腺癌的潜在遗传标记。结合ETS基因重排和抑癌基因PTEN缺失的数据，可以预测死于前列腺癌的风险。因此，代表跨大西洋前列腺小组工作的一组研究人员说。英国癌症研究所的主要作者艾里森·里德说：“利用基因状态，我们确定了一组表现很好的患者和一组表现非常差的患者。” “这些结果对于决定应保守或积极治疗哪些患者可能具有重要意义。”

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