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Sexual dysfunction: Rodent models of diabetic ED

机译:性功能障碍:糖尿病性ED的啮齿动物模型

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Erectile dysfunction (ED) is commonly reported in men with diabetes. Diabetic ED occurs at an earlier age than in the general population and is often refractory to treatment with phosphodiesterase type 5 inhibitors. This lack of response is thought to be due to either a more severe form of endothelial dysfunction observed in diabetic men compared with nondiabetic patients or via overactivation of the ROCK/RhoA signalling pathway. Treatment is currently focused on symptomatic relief and not cure. However, two recent studies published in the Journal of Sexual Medicine have investigated alternative therapeutic strategies and mechanisms for diabetic ED using rodent models, and one may possibly offer hope of a cure for diabetic ED using stromal vascular fraction (SVF) as a source of stem cells.
机译:糖尿病男性通常会出现勃起功能障碍(ED)。糖尿病性ED发生的年龄比一般人群早,并且通常难于用5型磷酸二酯酶抑制剂治疗。这种缺乏反应被认为是由于与非糖尿病患者相比在糖尿病男性中观察到的内皮功能异常更为严重,或者是由于ROCK / RhoA信号通路的过度激活所致。目前的治疗重点是症状缓解而非治愈。然而,最近发表在《性医学杂志》上的两项研究已经研究了使用啮齿动物模型治疗糖尿病性ED的其他治疗策略和机制,其中一项可能为利用基质血管分数(SVF)作为干源治疗糖尿病性ED提供了希望细胞。

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