• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature reviews. Urology >Isolated, disseminated and circulating tumour cells in prostate cancer
【24h】

Isolated, disseminated and circulating tumour cells in prostate cancer

机译：前列腺癌中分离，扩散和循环的肿瘤细胞

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The loss of single cells from a tumour cell cluster marks an early event in the metastatic process of cancer progression. Although the metastatic cascade in prostate cancer is yet to be fully understood, monitoring circulating tumour cells (CTCs) and quantifying the load of tumour cell dissemination is currently being implemented into routine clinical practice for diagnosing minimal residual disease (MRD), estimating prognosis and monitoring treatment success. Current methods for enrichment of CTCs or disseminated tumour cells (DTCs) and detection of MRD rely on the expression of specific marker genes or proteins that might be altered during the process of tumour cell dissemination, therefore disrupting tumour cell detection. The tumour origin and malignant potential for metastasis of marker-positive cells is not yet clear. Some studies have demonstrated the potential of CTCs or DTCs as prognostic or predictive markers, leading to the increasing implementation of CTC measurement as an end point in clinical trials.
机译：肿瘤细胞簇中单细胞的丢失标志着癌症进展转移过程中的早期事件。尽管尚未完全了解前列腺癌的转移级联，但目前正在常规临床实践中进行监测循环肿瘤细胞（CTC）和定量肿瘤细胞扩散的负荷，以诊断最小残留病（MRD），评估预后和监测治疗成功。当前富集CTC或已扩散的肿瘤细胞（DTC）和检测MRD的方法依赖于可能在肿瘤细胞扩散过程中改变的特定标记基因或蛋白质的表达，从而破坏了肿瘤细胞的检测。标记物阳性细胞的肿瘤起源和恶性转移潜力尚不清楚。一些研究表明CTC或DTC作为预后或预测指标的潜力，导致CTC测量作为临床试验终点的实施越来越多。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号