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Imaging: FMRI developments promise understanding of voiding dysfunction

机译:影像学检查:功能磁共振成像的发展有望了解排尿障碍

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In this review, we outline the concept and applicability of self-assembling dendrimers for gene-delivery applications. Low-molecular-weight, well-defined cationic dendritic arrays which have been modified with hydrophobic domains can form self-organized multivalent systems that have significant advantages over nonassembling, high-molecular-weight/polymeric gene vectors. Particular structural variations have been highlighted with respect to the individual components of the displayed dendritic amphiphiles, namely, the employed amine termini, the hydrophobic segment, the size of the dendritic array, and the integration of special features such as targeting ability and cleavability/degradability, which can all have a crucial effect on gene-transfection efficiencies. Accordingly, the scientific efforts to create new synthetic gene-delivery vectors to act as promising in vivo transfection agents in the future will be presented and discussed here.
机译:在这篇综述中,我们概述了自组装树状聚合物在基因传递应用中的概念和适用性。经过疏水域修饰的低分子量,定义明确的阳离子树突状阵列可以形成自组织的多价系统,与非组装的高分子量/聚合基因载体相比,它们具有明显的优势。关于所展示的树状两亲物的各个成分,即所用的胺末端,疏水链段,树状阵列的大小以及特殊功能(如靶向能力和可裂解性/降解性)的整合,已经特别强调了结构变化。 ,都可能对基因转染效率产生关键影响。因此,将在此介绍和讨论创建新的合成基因传递载体以在将来作为有希望的体内转染剂的科学努力。

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