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首页> 外文期刊>Nature reviews. Urology >Kidney cancer: decreased incidence of skeletal-related events in mRCC.
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Kidney cancer: decreased incidence of skeletal-related events in mRCC.

机译：肾脏癌：mRCC中骨骼相关事件的发生率降低。

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Benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) and erectile dysfunction commonly coexist, and both respond to phosphodiesterase (PDE) 5 inhibitors, suggesting a shared pathophysiological mechanism. We propose that both BPH-LUTS and erectile dysfunction are caused by microvascular dysfunction within the pelvic organs, and we present an overview of preclinical and clinical studies supporting the hypothesis that, within both the penis and the lower urinary tract, a combination of endothelial and neural dysfunction leads to a vicious cycle of hypoxia, vasoconstriction, altered smooth muscle contractility, and degeneration of autonomic neurons and ganglia. This hypothesis explains much of the preclinical and clinical research relating to these two conditions, and provides a rationale for further investigation into the effects of PDE5 inhibitors on the pathophysiology and symptoms of BPH-LUTS.
机译：良性前列腺增生（BPH）相关的下尿路症状（LUTS）和勃起功能障碍通常并存，并且都对磷酸二酯酶（PDE）5抑制剂有反应，表明存在共同的病理生理机制。我们认为BPH-LUTS和勃起功能障碍均是由盆腔器官内的微血管功能障碍引起的，并且我们对支持以下假说的临床前和临床研究进行了概述：假说在阴茎和下尿路内，内皮细胞和内皮细胞的结合神经功能障碍导致缺氧，血管收缩，平滑肌收缩力改变以及自主神经元和神经节变性的恶性循环。该假设解释了与这两种情况有关的许多临床前和临床研究，并为进一步研究PDE5抑制剂对BPH-LUTS的病理生理和症状的影响提供了理论依据。

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