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首页> 外文期刊>Nature reviews. Urology >Testicular cancer: Identifying occult metastatic seminoma using two small RNAs
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Testicular cancer: Identifying occult metastatic seminoma using two small RNAs

机译：睾丸癌：使用两个小RNA识别隐匿性转移性精原细胞瘤

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Researchers have identified a number of small RNAs that are differentially expressed in testicular tumours from patients with nonmetastatic and metastatic disease. Michael Abend and colleagues report that detection of just two of these small RNAs can completely discriminate between nonmetastatic and metastatic disease. About 30% of men with clinical stage 1 testicular seminoma are estimated to harbour occult metastases and, therefore, experience recurrence after orchidectomy. The ability to identify these patients before they undergo surgery would enable clinicians to tailor adjuvant treatment or follow-up monitoring accordingly, but the lack of appropriate predictive factors currently prevents such stratification.
机译：研究人员已经从非转移和转移性疾病患者的睾丸肿瘤中鉴定出许多差异表达的小RNA。 Michael Abend及其同事报告说，仅检测到这些小RNA中的两个即可完全区分非转移性疾病和转移性疾病。估计约有30％的临床1期睾丸精原细胞瘤患者具有隐匿性转移，因此，在切除兰花后会复发。这些患者在接受手术之前进行识别的能力将使临床医生能够相应地调整辅助治疗或随访监测，但是目前缺乏适当的预测因素阻止了这种分层。

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