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Basic research: Therapeutic action of BCG mediated by H 2 O 22?

机译:基础研究:H 2 O 22介导的卡介苗的治疗作用?

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The clinical effects of BCG on bladder cancer might be mediated by the production of hydrogen peroxide (H2O2), according to new research published online in The Journal of Urology. Despite BCG being an established treatment option for non-muscle-invasive bladder cancer, its mechanism of action remains unclear. Existing data largely suggest that BCG triggers an immune response in the bladder, leading to tumour cytotoxicity. However, BCG has also been shown to generate oxidative stress in the bladder. To investigate this association further, Gopitkumar Shah and colleagues at the Medical College of Wisconsin in Milwaukee, USA, performed a series of experiments to assess the relationship between cellular redox status and the antitumour effects of BCG.
机译:根据在线发表在《泌尿外科杂志》上的新研究,卡介苗对膀胱癌的临床作用可能是由过氧化氢(H2O2)的产生介导的。尽管BCG是非肌肉浸润性膀胱癌的既定治疗选择,但其作用机理仍不清楚。现有数据在很大程度上表明,BCG会触发膀胱中的免疫反应,从而导致肿瘤细胞毒性。但是,也已证明BCG会在膀胱中产生氧化应激。为了进一步研究这种关联,美国密尔沃基威斯康星医学院的Gopitkumar Shah及其同事进行了一系列实验,以评估细胞氧化还原状态与BCG抗肿瘤作用之间的关系。

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