Inflammatory mediators in the development and progression of benign prostatic hyperplasia

De Nunzio Cosimo; Presicce Fabrizio; Tubaro Andrea

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Inflammatory mediators in the development and progression of benign prostatic hyperplasia

机译：良性前列腺增生发生和发展中的炎性介质

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Benign prostatic hyperplasia (BPH) is the most common urological disease in elderly men. Epidemiological data suggest a causal link between this condition and prostatic inflammation. The prostate is an immune-competent organ characterized by the presence of a complex immune system. Several stimuli, including infectious agents, urinary reflux, metabolic syndrome, the ageing process, and autoimmune response, have been described as triggers for the dysregulation of the prostatic immune system via different molecular pathways involving the development of inflammatory infiltrates. From a pathophysiological standpoint, subsequent tissue damage and chronic tissue heating could result in the development of BPH nodules.

机译：良性前列腺增生（BPH）是老年男性最常见的泌尿科疾病。流行病学数据表明，这种情况与前列腺炎症之间存在因果关系。前列腺是一种具有免疫功能的器官，其特征是存在复杂的免疫系统。已经描述了几种刺激，包括感染原，尿液反流，代谢综合症，衰老过程和自身免疫反应，是通过涉及炎症浸润发展的不同分子途径引起前列腺免疫系统失调的诱因。从病理生理学的角度来看，随后的组织损伤和慢性组织发热可能导致BPH结节的发展。

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《Nature reviews. Urology》 |2016年第10期|共14页
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De Nunzio Cosimo; Presicce Fabrizio; Tubaro Andrea;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Inflammatory mediators in the development and progression of benign prostatic hyperplasia [J] . De Nunzio Cosimo, Presicce Fabrizio, Tubaro Andrea Nature reviews. Urology . 2016,第10期

机译：良性前列腺增生发生和发展中的炎性介质
2. The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia [J] . Rikiya Taoka, Yoshiyuki Kakehi Asian Journal of Urology . 2017,第3期

机译：无症状性炎症性前列腺炎对组织学良性前列腺增生男性下尿路症状发作和进展的影响
3. M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia [J] . Jindong Sheng, Yang Yang, Yun Cui, Cell death & disease. . 2018,第7期

机译：M2巨噬细胞介导的白细胞介素4信号在良性前列腺增生过程中诱导成肌纤维细胞表型
4. Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia [C] . Luciano Adorini, Giuseppe Penna, Benedetta Fibbi, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：维生素D受体激动剂靶向良性前列腺增生的静态，动态和炎症组分
5. The Feasibility of Fourier Transform Infrared Imaging Spectroscopy in Discriminating Benign Prostatic Hyperplasia From Prostate Cancer in Blood Serum Samples [D] . Monjardez, Geraldine. 2013

机译：傅里叶变换红外成像光谱技术从血清样品中区分前列腺癌与前列腺癌的可行性
6. Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes [O] . Melissa M. Norström, Emelie Rådestad, Berit Sundberg, 2016

机译：良性前列腺增生的进展与促炎介质和前列腺浸润淋巴细胞的慢性活化有关
7. Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population [O] . Zhiyong Ma, Norihiko Tsuchiya, Takeshi Yuasa, 2008

机译：成纤维细胞生长因子受体4的多态性与前列腺癌和良性前列腺增生和日本人口中前列腺癌的进展有关

Inflammatory mediators in the development and progression of benign prostatic hyperplasia

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