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首页> 外文期刊>Nature reviews. Urology >Testicular biopsy in prepubertal boys: a worthwhile minor surgical procedure?
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Testicular biopsy in prepubertal boys: a worthwhile minor surgical procedure?

机译：青春期前男孩的睾丸活检：值得进行小手术吗？

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No consensus exists regarding the precise role of testicular biopsy in prepubertal boys, although it is considered useful for assessing the potential consequences of undescended testes on fertility. Current scientific knowledge indicates that surgeons should broaden indications for this procedure. For example, the use of immunohistochemical markers such as OCT/3-4, TSPY, Kit ligand (SCF) and ALPP (PLAP) has considerably facilitated the detection of germ cell tumour precursors, such as carcinoma in situ and/or gonadoblastoma. These markers are very important for evaluating malignancy risk in undervirilized patients with 46,XY disorders of sexual development. Testicular histology is also of considerable value in the prediction of both fertility potential and risk of cancer in individuals with undescended testes, particularly those with intraabdominal undescended testes. New possibilities for the preservation of fertility after gonadotoxic chemotherapy - even for prepubertal boys - are emerging. Cryopreservation of testicular tissue samples for the preservation of fertility - although still an experimental method at present - is appealing in this context. In our opinion, testicular biopsy in prepubertal boys is a minor procedure that can provide valuable information for predicting the risk of malignancy and fertility, and might be useful in fertility preservation in the near future.
机译：关于睾丸活检在青春期前男孩中的确切作用尚无共识，尽管它被认为有助于评估睾丸未降对生育能力的潜在影响。当前的科学知识表明，外科医生应扩大此手术的适应症。例如，免疫组织化学标记物例如OCT / 3-4，TSPY，Kit配体（SCF）和ALPP（PLAP）的使用大大促进了生殖细胞肿瘤前体的检测，例如原位癌和/或成腺细胞瘤。这些标志物对于评估未充分免疫的46，XY性发育障碍患者的恶性肿瘤风险非常重要。睾丸组织学在预测睾丸未降，尤其是腹内睾丸未降的个体的生育潜力和癌症风险方面也具有重要价值。在性腺毒性化疗后，甚至对于青春期前男孩，保持生育能力的新可能性正在出现。在这种情况下，冷冻保存睾丸组织样本以保存生育力（尽管目前仍是一种实验方法）颇具吸引力。我们认为，青春期前男孩的睾丸活检是一个较小的步骤，可以为预测恶性肿瘤和生育力的风险提供有价值的信息，并且可能在不久的将来对生育力的保护有用。

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