首页> 外文期刊>Nature reviews. Urology >Bladder cancer: Plant lectins have the potential to facilitate targeted delivery of intravesical chemotherapy agents.
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Bladder cancer: Plant lectins have the potential to facilitate targeted delivery of intravesical chemotherapy agents.

机译:膀胱癌:植物凝集素具有促进膀胱内化疗药物靶向递送的潜力。

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摘要

Suboptimal urothelial delivery of adjuvant intravesical chemotherapy agents is currently a deficiency of this therapy in patients with bladder cancer. Neutsch eta/, found that various plant lectins, such as wheat germ and peanut agglutinins, showed good cytoadhesion and cytoinvasion of healthy and malignant urothelium, with some showing preferential uptake in cancer cells. These molecules could, therefore, represent novel, carbohydrate-based chemotherapy delivery systems.
机译:对于膀胱癌患者,目前尚无理想的尿道上皮辅助膀胱内化疗药物治疗方法。 Neutsch eta /发现,各种植物凝集素,例如小麦胚芽和花生凝集素,对健康和恶性尿道上皮表现出良好的细胞粘附性和细胞侵袭性,其中一些显示出对癌细胞的优先摄取。因此,这些分子可以代表新颖的,基于碳水化合物的化学疗法递送系统。

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