Prostate cancer: Who will win the CRPC drug race?

Clyne M

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Prostate cancer: Who will win the CRPC drug race?

机译：前列腺癌：谁将赢得CRPC药物竞赛？

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The race is on to find a safe and effective treatment option for delaying the progression of metastatic castration -resistant prostate cancer (CRPC). Although several contenders have surfaced in recent years, a clear winner has yet to break away from the pack. The current first-line standard of care is docetaxel. Cabazitaxel and abiraterone acetate have been approved as second-line therapies for docetaxol-resistant CRPC, but alternative therapies are urgently sought.

机译：竞赛正在寻找一种安全有效的方法来延缓转移性去势抵抗性前列腺癌（CRPC）的发展。尽管近年来有一些竞争者浮出水面，但显然有赢家尚未摆脱困境。当前的一线治疗标准是多西紫杉醇。卡巴他赛和醋酸阿比特龙已被批准为耐多西他赛的CRPC的二线疗法，但迫切需要替代疗法。

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《Nature reviews. Urology》 |2011年第11期|共1页
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Clyne M;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Prostate cancer: Who will win the CRPC drug race? [J] . Clyne M Nature reviews. Urology . 2011,第11期

机译：前列腺癌：谁将赢得CRPC药物竞赛？
2. Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC) [J] . Penning Trevor M. The Journal of Steroid Biochemistry and Molecular Biology . 2015,第Null期

机译：靶向抗抗抗腺轴抗腐蚀前列腺癌（CRPC）的耐药机制（CRPC）
3. Prostate cancer: Could an antimalarial drug delay the onset of CRPC? [J] . Melanie Clyne Nature reviews. Urology . 2013,第6期

机译：前列腺癌：抗疟药可以延迟CRPC的发作吗？
4. DRUG ACCUMULATION INTO SINGLE DRUG-SENSITIVE AND DRUG-RESISTANT PROSTATE CANCER CELLS CONDUCTED ON THE SINGLE CELL BIOANALYZER [C] . Avid Khamenehfar, Ji Liu, Jia Cai, ASME International Mechanical Engineering Congress and Exposition . 2015

机译：对单细胞生物分析仪进行单一药物敏感和耐药前列腺癌细胞的药物积累
5. Mechanism of Extracellular Matrix Induced Tumor Survival and Drug Resistance in Castration-Resistant Prostate Cancer [D] . Chaudhary, Pooja. 2019

机译：细胞外基质诱导肿瘤存活和抗阉割前列腺癌的耐药机制
6. Mechanisms of Drug Resistance that Target the Androgen Axis in Castration Resistant Prostate Cancer (CRPC) [O] . Trevor M. Penning -1

机译：靶向去势抵抗性前列腺癌（CRPC）中雄激素轴的耐药机制
7. GT75 aptamer against eukaryotic elongation factor 1A as potential anticancer drug for castrate-resistant prostate cancer (CRPC). [O] . Bruna Scaggiante, Barbara Dapas, Alessandra Bosutti, 2014

机译：抗真核生物延伸因子1A的GT75适体作为去势抵抗性前列腺癌（CRPC）的潜在抗癌药。
8. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

机译：跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体（aR）在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

Prostate cancer: Who will win the CRPC drug race?

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