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Proposed mechanisms of action for prostate cancer vaccines

机译：前列腺癌疫苗的拟议作用机制

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Prostate cancer is responsible for the deaths of more than 33,000 American men every year. Once this disease has become metastatic, there is no curative treatment. Alternative therapies to chemotherapy and radical prostatectomy are being increasingly explored. Prostate cancer vaccines - which trigger a tumour-specific cytotoxic-T-lymphocyte-mediated immune attack by the patient's immune system - have been investigated in clinical trials with modest, yet encouraging, results. When developing and administering prostate cancer vaccines, it is critical to consider how vital parameters, such as the stage of disease progression and the nature of adjuvant therapies, could influence treatment outcome. Of particular interest are current and future strategies for diminishing the activity of regulatory T lymphocytes. ? 2013 Macmillan Publishers Limited.
机译：每年，前列腺癌是造成33,000多名美国男子死亡的原因。一旦这种疾病转移，就没有治愈的方法。越来越多地探索化学疗法和前列腺癌根治术的替代疗法。前列腺癌疫苗-由患者的免疫系统引发肿瘤特异性的细胞毒性T淋巴细胞介导的免疫攻击-已在临床试验中进行了研究，结果适中，但令人鼓舞。在开发和给药前列腺癌疫苗时，至关重要的是要考虑关键参数，例如疾病进展的阶段和辅助疗法的性质如何影响治疗结果。减少调节性T淋巴细胞活性的当前和未来策略尤为重要。 ？ 2013 Macmillan Publishers Limited。

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