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首页> 外文期刊>Nature reviews. Urology >The interplay of extracellular matrix and microbiome in urothelial bladder cancer
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The interplay of extracellular matrix and microbiome in urothelial bladder cancer

机译：尿路上皮癌中细胞外基质与微生物组的相互作用

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Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. In urological research, assessment of their dysregulation has become increasingly important to provide diagnostic, prognostic and predictive biomarkers for urothelial bladder cancer. Understanding the roles of the extracellular matrix and microbiota, two key components of the urothelial mucosa, in the sequelae of pathogenic events that occur in the development and progression of urothelial carcinomas will be important to overcome the shortcomings in current bladder cancer treatment strategies.
机译：实体肿瘤的许多病理变化是由基因突变和表观遗传分子的积累引起的。另外，肿瘤进展受到转化细胞周围环境的深刻影响。肿瘤细胞与其微环境之间的相互作用已被认为是癌症发展的关键决定因素之一，并且正在被广泛研究。数据表明，细胞外基质和微生物群均代表有助于肿瘤发作和发展的微环境。通过引入组学技术和焦磷酸测序分析，现在可以对这两种微环境进行详细研究。在泌尿科研究中，对其功能失调的评估对于为尿路上皮膀胱癌提供诊断，预后和预测性生物标志物已变得越来越重要。了解尿路上皮粘膜的两个关键组成部分细胞外基质和微生物群在尿路上皮癌的发展和进程中发生的致病事件的后遗症中的作用，对于克服当前膀胱癌治疗策略中的缺点将是重要的。

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