Translational control by changes in poly(A) tail length: Recycling mRNAs

Weill L.; Belloc E.; Bava F.-A.; Méndez R.

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Translational control by changes in poly(A) tail length: Recycling mRNAs

机译：通过改变poly（A）尾巴长度的翻译控制：回收mRNA。

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Beyond the well-known function of poly(A) tail length in mRNA stability, recent years have witnessed an explosion of information about how changes in tail length and the selection of alternative polyadenylation sites contribute to the translational regulation of a large portion of the genome. The mechanisms and factors mediating nuclear and cytoplasmic changes in poly(A) tail length have been studied in great detail, the targets of these mechanisms have been identified - in some cases by genome-wide screenings - and changes in poly(A) tail length are now implicated in a number of physiological and pathological processes. However, in very few cases have all three levels - mechanisms, targets and functions - been studied together.

机译：除了众所周知的poly（A）尾巴长度在mRNA稳定性中的功能外，近年来目睹了有关尾巴长度变化和备选聚腺苷酸化位点的选择如何促进大部分基因组翻译调控的信息的爆炸式增长。已经详细研究了介导poly（A）尾巴长度的核和细胞质变化的机制和因素，已经确定了这些机制的目标-在某些情况下通过全基因组筛选-以及poly（A）尾巴长度的变化现在与许多生理和病理过程有关。然而，在极少数情况下，同时研究了这三个层次（机制，目标和功能）。

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《Nature structural & molecular biology》 |2012年第6期|共9页
作者
Weill L.; Belloc E.; Bava F.-A.; Méndez R.;
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正文语种 eng
中图分类分子生物学;
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1. Translational control by changes in poly(A) tail length: Recycling mRNAs [J] . Weill L., Belloc E., Bava F.-A., Nature structural & molecular biology . 2012,第6期

机译：通过改变poly（A）尾巴长度的翻译控制：回收mRNA。
2. FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control [J] . Legnini Ivano, Alles Jonathan, Karaiskos Nikos, Nature methods . 2019,第9期

机译：FLAM-SEQ：全长mRNA测序显示Poly（a）尾部长度控制的原理
3. Molecular dissection of mRNA poly(A) tail length control in yeast [J] . Viphakone N, Voisinet-Hakil F, Minvielle-Sebastia L Nucleic Acids Research . 2008,第7期

机译：酵母中mRNA poly（A）尾部长度控制的分子解剖
4. Translational Control by Differential CAP-dependency in Selected Subpopulations of Maize-stored mRNAs [C] . TZVETANKA D. DINKOVA, RAUL AGUILAR, ESTELA SANCHEZ DE JIMENEZ International Workshop on Seeds . 2003

机译：差分帽依赖性在玉米储存MRNA的选定亚级依赖的平移控制
5. The role of the cap and poly(A) tail in mRNA metabolism [D] . Meaux, Stacie Ann 2008

机译：帽和poly（A）尾巴在mRNA代谢中的作用
6. Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation [O] . Ming Shao, Tong Lu, Chong Zhang, 2020

机译：Rbm24通过细胞质聚腺苷酸化作用控制晶状体中的结晶蛋白mRNA的poly（A）尾长和翻译效率
7. DAZL Relieves miRNA-Mediated Repression of Germline mRNAs by Controlling Poly(A) Tail Length in Zebrafish [O] . Takeda, Yasuaki, Mishima, Yuichiro, Fujiwara, Toshinobu, 2009

机译：DAZL通过控制斑马鱼的Poly（A）尾巴长度减轻miRNA介导的生殖细胞mRNA的阻遏。

Translational control by changes in poly(A) tail length: Recycling mRNAs

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