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首页> 外文期刊>Neoplasma: Journal of Experimental and Clinical Oncology >CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients.
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CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients.

机译：CYP和GST多态性与晚期非小细胞肺癌患者的生存率。

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摘要

Several polymorphisms in cytochrome P-450s (CYP)s and Glutathione S-transferases (GST)s have been reported to be associated with survival rates of patients with non-small cell lung cancer (NSCLC) but the studies in this regard are scarce and the results are contradictory. In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Ala114Val) and GSTT1 polymorphisms were determined in 138 patients with advanced NSCLC to evaluate their role in survival. Of the studied CYP and GST polymorphisms only GSTP1 exon 6 variant significantly altered (improved) the survival compared to wild type (p=0.036) with median survival of 22.2 months and 16.1 months, respectively. Multivariate analysis also revealed a significant reduction of adjusted hazard ratio of death associated only with the GSTP1 exon 6 variant genotype of 0.45 (95% confidence interval (95% CI), 0.23-0.89, p=0.022). These results show that the GSTP1 exon 6 variant genotype is associated with improved survival in the patients with advanced NSCLC. Keywords: Cytochrome P-450, glutathione S-transferase, non small cell lung cancer, polymorphism, survival.
机译：据报道，细胞色素P-450（CYP）和谷胱甘肽S-转移酶（GST）的几种多态性与非小细胞肺癌（NSCLC）患者的存活率有关，但是在这方面的研究很少，而且结果是矛盾的。在这项研究中，确定了138位晚期NSCLC患者的CYP1A1（Ile462Val），CYP1B1（Asn453Ser），GST M1，GSTP1外显子5（Ile105Val）和外显子6（Ala114Val）和GSTT1多态性，以评估其在生存中的作用。在研究的CYP和GST多态性中，与野生型（p = 0.036）相比，只有GSTP1外显子6变异显着改变（提高）存活率，中位生存期分别为22.2个月和16.1个月。多变量分析还显示，仅与GSTP1外显子6变异基因型0.45（95％置信区间（95％CI），0.23-0.89，p = 0.022）相关的调整后的死亡危险比显着降低。这些结果表明，GSTP1外显子6变异基因型与晚期NSCLC患者的生存期改善有关。关键词：细胞色素P-450，谷胱甘肽S-转移酶，非小细胞肺癌，多态性，存活率。

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