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首页> 外文期刊>Neoplasma: Journal of Experimental and Clinical Oncology >Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line.
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Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line.

机译：从罂粟提取的植物提取物对人淋巴母细胞系的生物活性。

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摘要

Varied medicinal plants are known as a source of natural phytochemicals with antioxidant activities that can protect organisms from oxidative stress and from various chronic diseases. Papaver rhoeas has a long history of medicinal usage, especially for ailments in adults and children. The possible cytotoxicity, genotoxicity and potential antioxidant effect of plant extract isolated from flowers of Papaver rhoeas was investigated in human lymfoblastoid cell line (TK6). Antioxidant activity of this extract was determined using the DPPH assay. The plant extract exhibited dose dependent free radical scavenging ability. The growth activity assay was used for determination of cytotoxicity. To assess potential genotoxicity the comet assay was used. The lower extract concentrations (0.25 and 0.5 mg/ml) neither exerted cytotoxic, nor genotoxic effects in TK6 cells but they stimulated cell proliferation. The concentration 25 mg/ml scavenged almost 85% of DPPH free radical. On the other hand, this concentration had strong cytotoxic and genotoxic effect on TK6 cells. The balance between beneficial and harmful effects should be always considered when choosing the effective dose.
机译：各种各样的药用植物被称为具有抗氧化活性的天然植物化学物质的来源，可以保护生物体免受氧化应激和各种慢性疾病的侵害。罂粟粉具有很长的药用历史，尤其是成人和儿童的疾病。在人淋巴母细胞样细胞系（TK6）中研究了从罂粟属花中提取的植物提取物可能的细胞毒性，遗传毒性和潜在的抗氧化作用。使用DPPH测定法测定该提取物的抗氧化活性。植物提取物表现出剂量依赖性的自由基清除能力。使用生长活性测定法测定细胞毒性。为了评估潜在的遗传毒性，使用了彗星试验。较低的提取物浓度（0.25和0.5 mg / ml）在TK6细胞中既没有发挥细胞毒性，也没有遗传毒性，但是它们刺激了细胞增殖。 25 mg / ml的浓度清除了几乎85％的DPPH自由基。另一方面，该浓度对TK6细胞具有强的细胞毒性和遗传毒性作用。选择有效剂量时，应始终考虑利弊之间的平衡。

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