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首页> 外文期刊>Neurotoxicology >Different effects by sex on hypothalamic-pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP)
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Different effects by sex on hypothalamic-pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP)

机译：性别对子宫内和哺乳期邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露产生的青春期前子代大鼠下丘脑-垂体轴的不同影响

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This study investigated the effect of pre and perinatal exposure to di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that regulate reproduction in prepubertal male and female rats. DEHP at doses of 3 and 30 mg/kg. bw/day was administered orally in the drinking water to dam rats since pregnancy onset until the moment of pups sacrifice at 15 days of age. In these animals gonadotropin serum level and the hypothalamic contents of the amino acids aspartate, glutamate and gamma-aminobutyric acid were determined. No changes in gonadotropin levels and amino acid neurotransmitters were detected at the low dose in both sexes. However, DEHP administered at high dose (30 mg/kg bw/day) to dams produced a significant decrease in the inhibitory neurotransmitter GABA and an increase in the stimulatory neurotransmitter aspartate in prepubertal male offspring rats. These modifications were accompanied by gonadotropin serum levels increase. On the contrary, in treated female rats this chemical increased both, aspartate and GABA, which exert a characteristic stimulatory action on gonadotropin in 15-day-old normal females. This study provides new data about changes produced by DEHP on the hypothalamic amino acid neurotransmitters involved in the neuroendocrine reproductive regulation, in prepubertal male and female rat offspring from dams exposed during gestational and lactational periods. These alterations induced by DEHP exposure could be related to the gonadotropin modifications also described in this work, and with changes in the production of sexual hormones previously reported by other authors.
机译：这项研究调查了产前和围产期暴露于邻苯二甲酸二（2-乙基己基）酯（DEHP）对调节青春期前雄性和雌性大鼠神经内分泌参数的影响。 DEHP的剂量为3和30 mg / kg。自怀孕开始至禁食大鼠口服bw / day，直到15日龄幼崽处死。在这些动物中，测定了促性腺激素的血清水平和天门冬氨酸，谷氨酸和γ-氨基丁酸氨基酸的下丘脑含量。在男女中低剂量时均未检测到促性腺激素水平和氨基酸神经递质的变化。然而，以高剂量（30 mg / kg bw /天）对大坝施用DEHP会导致青春期前雄性后代大鼠的抑制性神经递质GABA显着降低，而刺激性神经递质天冬氨酸的升高。这些修饰伴随促性腺激素血清水平升高。相反，在接受治疗的雌性大鼠中，该化学物质增加了天冬氨酸和GABA的含量，这对15天大的正常雌性动物的促性腺激素具有特征性的刺激作用。这项研究提供了有关DEHP在妊娠和哺乳期暴露于水坝的青春期前雄性和雌性大鼠后代中参与神经内分泌生殖调节的下丘脑氨基酸神经递质变化的新数据。由DEHP暴露引起的这些改变可能与这项工作中也描述的促性腺激素修饰有关，并且与其他作者先前报道的性激素产生变化有关。

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