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首页> 外文期刊>Neurourology and urodynamics. >Nocturnal polyuria and nocturnal arginine vasopressin (AVP): a key factor in the pathophysiology of monosymptomatic nocturnal enuresis.
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Nocturnal polyuria and nocturnal arginine vasopressin (AVP): a key factor in the pathophysiology of monosymptomatic nocturnal enuresis.

机译：夜间多尿和夜间精氨酸加压素（AVP）：单症状性夜间遗尿症的病理生理学中的关键因素。

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AIMS: To identify the relationship between nocturnal AVP deficiency, nocturnal polyuria (NP), and low urinary osmolality in children suffering of primary monosymptomatic nocturnal enuresis (NE). PATIENTS AND METHODS: The study included 50 children (28 males and 22 females) with primary monosymptomatic NE and 30 non enuretic children of the same age group (controls). Night samples of blood and urine were obtained for AVP, blood osmolality, and urine osmolality. In addition, volume frequency charts, arousal threshold, and urodynamics were performed for these children. RESULTS: Twenty eight (56%) of the enuretic children were considered to have NP. Mean AVP level was 44.80 +/- 8.19 and 32.49 +/- 18.25 pg/ml while mean urine osmolality was 865.07 +/- 158.66 mOsm/kg and 700.06 +/- 84.42 mOsm/kg in controls and enuretic group respectively. These differences were highly significant. No significant difference was found between the controls and enuretics without NP. On the other hand, nocturnal AVP and urine osmolality were significantly lower in enuretics with NP when compared to both controls and enuretics without NP. Blood osmolality did not reach statistically significant difference between subgroups. Arousal threshold was significantly higher in enuretic children irrespective to NP. The timing for NE episodes were predominantly late in the night in NE children without NP while patients suffering of NE with NP typically experienced multiple incidents each night. CONCLUSION: We have shown that low nocturnal AVP and urine osmolality may play a role in the pathophysiology of enuretics with NP. This abnormality doesn't occur as an isolated disease as these children suffer from arousal defect as well.
机译：目的：确定患有原发性单症状性夜间遗尿症（NE）的儿童夜间AVP缺乏症，夜间多尿症（NP）和低尿渗透压之间的关系。病人和方法：该研究包括50名患有原发性单症状NE的儿童（28名男性和22名女性）和30名同一年龄组的非尿毒症儿童（对照组）。获得夜间血液和尿液样品的AVP，血液渗透压和尿渗透压。此外，还对这些儿童进行了容积频率图表，唤醒阈值和尿流动力学检查。结果：28名（56％）的小儿被认为患有NP。对照组和遗尿组的平均AVP水平分别为44.80 +/- 8.19和32.49 +/- 18.25 pg / ml，而平均尿渗透压为865.07 +/- 158.66 mOsm / kg和700.06 +/- 84.42 mOsm / kg。这些差异非常重要。对照组和没有NP的尿毒症之间没有发现显着差异。另一方面，与对照组和无NP者相比，NP者的夜间AVP和尿渗透压明显降低。在各亚组之间，血液渗透压没有达到统计学上的显着差异。尿毒症儿童的门槛明显高于NP。在没有NP的NE儿童中，NE发作的时间主要是在深夜，而患有NP的NE的患者通常每晚都经历多次事件。结论：我们发现低夜间AVP和尿渗透压可能与NP的尿毒症患者的病理生理有关。这些异常不会作为孤立的疾病发生，因为这些孩子也患有唤醒缺陷。

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