• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve.
【24h】

Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve.

机译：肿瘤坏死因子促进周围神经压迫的运动功能恢复。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The potential benefits of tumor necrosis factor pretreatment in promoting motor functional recovery of peripheral nerve following low load crush injury were examined. Using a specially designed crush device, rat sciatic nerve was subjected to a low load crush injury of 2-h duration. Recombinant murine tumor necrosis factor and saline were intraperitoneally injected into the experimental and control animals, respectively, prior to nerve crushing. Subsequent motor function was evaluated at intervals by measurement of the sciatic functional index. There was significantly (P < 0.05 to < 0.01) more rapid recovery in the tumor necrosis factor pretreated group as compared to the controls between day 14 and day 28. The sciatic functional index in the tumor necrosis factor group improved to -69.3 +/- 5.3 at day 14 and to nearly normal at day 21. In contrast, the sciatic functional index in the control group was -95.5 +/- 3.1% at day 14 and did not approach normal until day 42. Histological results paralleled the functional findings. The results suggest that tumor necrosis factor pretreatment has the potential to attenuate neurostructural damage and promote motor functional recovery in rat peripheral nerve.
机译：研究了肿瘤坏死因子预处理在促进低负荷挤压伤后促进周围神经运动功能恢复方面的潜在益处。使用专门设计的挤压装置，大鼠坐骨神经遭受持续2小时的低负荷挤压损伤。在压碎神经之前，分别将腹腔注射重组鼠肿瘤坏死因子和盐水到实验动物和对照动物中。随后通过测量坐骨神经功能指数来评估随后的运动功能。在第14天至第28天之间，与肿瘤坏死因子预处理组相比，肿瘤坏死因子预处理组的恢复快得多（P <0.05至<0.01）。肿瘤坏死因子组的坐骨神经功能指数提高至-69.3 +/-在第14天时为5.3，在第21天时接近正常。相比之下，对照组的坐骨神经功能指数在第14天时为-95.5 +/- 3.1％，直到第42天才接近正常。组织学结果与功能性发现平行。结果表明，肿瘤坏死因子预处理具有减轻大鼠神经周围神经结构损伤和促进运动功能恢复的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号